ID U6LC79_EIMTE Unreviewed; 273 AA.
AC U6LC79;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Aldo/keto reductase family oxidoreductase, putative {ECO:0000313|EMBL:CDJ45355.1};
GN ORFNames=ETH_00020355 {ECO:0000313|EMBL:CDJ45355.1};
OS Eimeria tenella (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5802 {ECO:0000313|EMBL:CDJ45355.1};
RN [1] {ECO:0000313|EMBL:CDJ45355.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ45355.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ45355.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ45355.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HG678175; CDJ45355.1; -; Genomic_DNA.
DR RefSeq; XP_013236101.1; XM_013380647.1.
DR AlphaFoldDB; U6LC79; -.
DR EnsemblProtists; CDJ45355; CDJ45355; ETH_00020355.
DR GeneID; 25253199; -.
DR VEuPathDB; ToxoDB:ETH2_1137000; -.
DR VEuPathDB; ToxoDB:ETH_00020355; -.
DR OMA; LWNSQHH; -.
DR OrthoDB; 5305445at2759; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF15; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
FT DOMAIN 4..257
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 37
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 94
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 60
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 273 AA; 30787 MW; 1220A798B39DF631 CRC64;
MPVIGLGTWR LRGDRLRSGV FGALHERYGL IDTASVYGNE EEIRQLLKEA GNPRVFLTSK
LKPEDAQGTE AVLKAFEGTI ERLGVEQLDL YLIHWPGSGG VDANSPANRQ RRLESWRALE
QLYEKKKVRA IGVSNFLVPH IEQLMEDGAK IMPMVNQLEW HPMCWVPDLI PFAKKHSIVL
QAYSSLGSGE NRLLDHPVVK EIAKEINQPP SVVLLGWPRQ QGLLIIPCST SQEHLKENLA
ALTVQLSEDQ MKRLGAIHED VKHRFCWDPN TIA
//
