ID   U6RCE7_9BACE            Unreviewed;       718 AA.
AC   U6RCE7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Alpha-glucosidase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1214_04139 {ECO:0000313|EMBL:EOA54314.1};
OS   Bacteroides sp. HPS0048.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1078089 {ECO:0000313|EMBL:EOA54314.1, ECO:0000313|Proteomes:UP000017815};
RN   [1] {ECO:0000313|EMBL:EOA54314.1, ECO:0000313|Proteomes:UP000017815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HPS0048 {ECO:0000313|EMBL:EOA54314.1,
RC   ECO:0000313|Proteomes:UP000017815};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA   Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Bacteroides sp. HPS0048.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOA54314.1}.
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DR   EMBL; AGEU01000062; EOA54314.1; -; Genomic_DNA.
DR   RefSeq; WP_002562020.1; NZ_KB905490.1.
DR   AlphaFoldDB; U6RCE7; -.
DR   PATRIC; fig|1078089.3.peg.4077; -.
DR   HOGENOM; CLU_011166_2_0_10; -.
DR   OrthoDB; 1109141at2; -.
DR   Proteomes; UP000017815; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   Gene3D; 2.70.98.10; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   InterPro; IPR029483; GH97_C.
DR   InterPro; IPR019563; GH97_catalytic.
DR   InterPro; IPR029486; GH97_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR35803:SF1; GLUCAN 1,4-ALPHA-GLUCOSIDASE SUSB; 1.
DR   PANTHER; PTHR35803; GLUCAN 1,4-ALPHA-GLUCOSIDASE SUSB-RELATED; 1.
DR   Pfam; PF14509; GH97_C; 1.
DR   Pfam; PF14508; GH97_N; 1.
DR   Pfam; PF10566; Glyco_hydro_97; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..718
FT                   /note="Alpha-glucosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004679890"
FT   DOMAIN          29..295
FT                   /note="Glycosyl-hydrolase 97 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14508"
FT   DOMAIN          300..601
FT                   /note="Glycosyl-hydrolase 97 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF10566"
FT   DOMAIN          604..704
FT                   /note="Glycosyl-hydrolase 97 C-terminal oligomerisation"
FT                   /evidence="ECO:0000259|Pfam:PF14509"
SQ   SEQUENCE   718 AA;  81290 MW;  7CA96680545F956F CRC64;
     MINMKTLTIK MAFFLLALLI STAAMAESIT SPNGLLKLNF SVNAQGEPVY ELSYKDKEVI
     KPSKLGLELK NDPGLMNGFT LTDAKTSTFD ETWEPVWGEV KSIRNHYNEL AVTLDQKAQD
     RNIVIRFRLY DDGLGFRYEF PLQKNLNYFV IKEEHSQFAM TGDHTAFWIP GDYDTQEYDY
     TESKLSEIRG LMNGAITDNA SQASFSPTGV QTSLQMKTAD GLYINLHEAA LVDYSCMNLN
     LDDKNLVFES WLTPDAVGDK GYMQTPCKSP WRTVIVSDDA RDILASKLTL NLNDPCAYED
     VSWIKPVKYV GVWWEMITGK SSWAYTDDVL SVKLGETDYS KTKPNGKHGA NNENVKRYID
     FAAEHGFDQV LVEGWNEGWE DWFGHSKDYV FDFVTAYPDF DVKMLNDYAK SKGVKLMMHH
     ETSASVRNYE RHMDKAYQFM VDNGYNAVKS GYVGNIIPRG EHHYGQWMNN HYLYAVKKAA
     DYKICVNAHE AVRPTGLCRT YPNLIGNESA RGTEYEAFGG SKPFHTTLLP FTRQIGGPMD
     YTPGLFDTQL SFLTGEHSFV HTTLAKQLAL YLTMYSPLQM AADLPENYER YMDAFQFIKD
     VAVDWDDSKY LEAEPGDYIT VARKAKGTNN WFVGGITDEN ARTSTFTLDF LEPGKQYVAT
     LYADGKDADY ESNPTSYQIK KGLVTNKTKI STKLARSGGF AMSIIEAAPA DKKMKKFK
//