ID U6RIC8_9BACE Unreviewed; 765 AA.
AC U6RIC8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=HMPREF1214_04028 {ECO:0000313|EMBL:EOA54923.1};
OS Bacteroides sp. HPS0048.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1078089 {ECO:0000313|EMBL:EOA54923.1, ECO:0000313|Proteomes:UP000017815};
RN [1] {ECO:0000313|EMBL:EOA54923.1, ECO:0000313|Proteomes:UP000017815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HPS0048 {ECO:0000313|EMBL:EOA54923.1,
RC ECO:0000313|Proteomes:UP000017815};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroides sp. HPS0048.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOA54923.1}.
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DR EMBL; AGEU01000058; EOA54923.1; -; Genomic_DNA.
DR RefSeq; WP_002561912.1; NZ_KB905490.1.
DR AlphaFoldDB; U6RIC8; -.
DR PATRIC; fig|1078089.3.peg.3967; -.
DR HOGENOM; CLU_007082_5_0_10; -.
DR OrthoDB; 1090159at2; -.
DR Proteomes; UP000017815; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 3.90.182.10; Toxin - Anthrax Protective Antigen;domain 1; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF13290; CHB_HEX_C_1; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR Pfam; PF07691; PA14; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SMART; SM00758; PA14; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR PROSITE; PS51820; PA14; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..765
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004676427"
FT DOMAIN 628..762
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT ACT_SITE 348
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 765 AA; 85928 MW; B238EB6D9BEF136E CRC64;
MLKKLCFSLL AMSAYILSSC SGPSARQEVA VLPTPVQLTT QSGMFVLKNG LKIGVSDESL
LPAAQYLQTI LQNAVISTAE VGGQPADIFL KLTDTKGKEG AYKLNVTSGN IVAEAADYSG
IISAISTLRQ LLPAAIEQSS QDASHSIPAV SIEDAPRLAW RGMMLDASRH FWNKEEVKHV
LDMMALYKLN KFHWHLTDDQ GWRIEIKQYP LLTAKGAWRK FNSHDRECMH RMVEEDNLDF
RIPEDKMEIV EGDTLYGGYY TQDDIKEIVA YAAQRGIDVI PEIDMPGHFL AAINQYPEIA
CTGLIGWGSV FSSPICPGKD STLEFCKNVY KEVFQLFPYM YVHMGGDEVD MANWKKCADC
QRRMKREGIQ SENGLQAWFV RQMETFFMEN GKKFIGWDEV IADGLSDNAT IMWWRSWAPK
AIPTATSEGK QVINTENNYF YFDYLQDKTT LPKLLAYEPI PAELTPEQQK RVLGVQANFW
CEWIPSMKRL EYMMMPRLLA LSEIAWVEPS AKPNIDDFYK ALIPQFKRLD AMNINYRIPD
LEGFYNTNAF VDEATLDIKC PLPDAEIRYT TDGKFPTKAS QLYEGPLKVT ETTEFTLRTF
RPDGSACDMV KTKLVKAPYA EADSTAAVSG DGLNVVWHDF KGEKCADIDA APVKDTYVVE
TVSIPEGVKG DIGLVLKGYL QVPVDGIYTL ALLSDDGSTL LIDGKLLIDN DGPHSPREVI
AQVTLKEGLH PIEIRYFDNN GGTLEMSLIN EKGEKQILGK DWLKH
//
