ID U6RX53_9BACE Unreviewed; 1485 AA.
AC U6RX53;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=BIG2 domain-containing protein {ECO:0000259|SMART:SM00635};
GN ORFNames=HMPREF1214_00089 {ECO:0000313|EMBL:EOA60666.1};
OS Bacteroides sp. HPS0048.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1078089 {ECO:0000313|EMBL:EOA60666.1, ECO:0000313|Proteomes:UP000017815};
RN [1] {ECO:0000313|EMBL:EOA60666.1, ECO:0000313|Proteomes:UP000017815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HPS0048 {ECO:0000313|EMBL:EOA60666.1,
RC ECO:0000313|Proteomes:UP000017815};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroides sp. HPS0048.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the polysaccharide lyase 8 family.
CC {ECO:0000256|ARBA:ARBA00006699}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOA60666.1}.
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DR EMBL; AGEU01000002; EOA60666.1; -; Genomic_DNA.
DR RefSeq; WP_002558104.1; NZ_KB905487.1.
DR PATRIC; fig|1078089.3.peg.85; -.
DR HOGENOM; CLU_249430_0_0_10; -.
DR OrthoDB; 6394136at2; -.
DR Proteomes; UP000017815; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR CDD; cd01083; GAG_Lyase; 1.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.220.10; Polysaccharide lyase family 8-like, C-terminal; 1.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR008929; Chondroitin_lyas.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR038970; Lyase_8.
DR InterPro; IPR011071; Lyase_8-like_C.
DR InterPro; IPR012970; Lyase_8_alpha_N.
DR InterPro; IPR004103; Lyase_8_C.
DR InterPro; IPR003159; Lyase_8_central_dom.
DR InterPro; IPR026444; Secre_tail.
DR NCBIfam; TIGR04183; Por_Secre_tail; 1.
DR PANTHER; PTHR38481; HYALURONATE LYASE; 1.
DR PANTHER; PTHR38481:SF1; HYALURONATE LYASE; 1.
DR Pfam; PF02368; Big_2; 1.
DR Pfam; PF15892; BNR_4; 1.
DR Pfam; PF02278; Lyase_8; 1.
DR Pfam; PF02884; Lyase_8_C; 1.
DR Pfam; PF08124; Lyase_8_N; 1.
DR Pfam; PF18962; Por_Secre_tail; 1.
DR SMART; SM00635; BID_2; 1.
DR SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
DR SUPFAM; SSF89372; Fucose-specific lectin; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF49863; Hyaluronate lyase-like, C-terminal domain; 1.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1485
FT /note="BIG2 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004678779"
FT DOMAIN 446..522
FT /note="BIG2"
FT /evidence="ECO:0000259|SMART:SM00635"
SQ SEQUENCE 1485 AA; 163145 MW; F643FB5607FE214C CRC64;
MKHLLTTLSL GALLLMGGPT TVQAEKVTVP LTEDGAWSFN SQPSAVYYNG KTYFTWISSS
KALVVASYDH TTGETKEKVV STGYSDDFSS PAITVRGNGQ LLLFSSDNKK ENGFYSWYST
NAEDITEWSS SQKQTGYGIS STTPHMVGND LVVFWRSKNN IGYSLFTNVA DKTGNLPAVK
TRAGFIGSDI GNAYAKRDEV PQMRTYQAAD GTIHMVVTHL GTGLTYKNST VHYLKINKNA
TGDKLEFKKA DGTAISGMNV TESKSSELDV IAKGEDTNKV WAYDIALDAS GNPVVLYDAF
TAAEDGTTTG HTYYYARWNG TAWESTAITT GDGVPMSEYK AVEGNIFKAK SYQAGGICFG
ANDLNTVYLS KKAAEGTFEI YRYETTDNGA TWAEKEVITS GTPAGELNIR PIAIKDAPAD
VFWMQGMYDN PTNYKTSISC AGEGVATTGI FFGQDSYEFV ANETTNLDVR FAPLFATDKE
YTLESSNTGV VEITADGKVL CKATGEATIT AKLKNNASVS TTCKVTVLGE SVYKTFINRI
ITDVVASKIS TIDQLDKNVA SYLTQLQDDG SFPDIDYASD ARTDWPPMQH LDRLLAMGLA
YTQTESKYYG NDELKAKMDL MLTYWHSKQP SSNNWYQNQI GEPQRMGQYL IVMQNLGKEK
ISEDLFNKSI ARLKNKGGSP SSQTGANRVD VALHWMYRAC LTEDDNLMRE AMDQIYSTIE
YTTGAEGIQY DNSFTQHGHQ LHIGAYGDVF LDGITKACSY AAGTRFTVTG QQLDILSSLV
NTYIGTIRGG YMSYNVIGRS STRPGATKKG TGIIERMIAL DPANTDKYEK TIARINGTQQ
PSYGLEPRST HFFRGDYTLH QRPEYTVDLR LVSTRTARNE YLKDNGEGIK QYFMSDGSTA
IMVKGNEYYN IFPVWNYAKV PGVTCPEFTE IPQASTYIKM GQSAFAGGVT DSLCSVSAYK
YIDNEFNINS SANKAWFFFD KEIVCLGNSI KSASEFQVNT TVNQCLLDGD VVVSSNGSES
TLQAGDYNYE DNLDWAFHGN VGYYFPQKGK LQLNAGERTG NWYDINTNYA DETVKNNVFT
LSFNHGTQPT DGSYAYIIVP GISKDDAKAY KSDNVEIIIN TDSVQAVYHK ELKMYGLVFY
KSAGFSKHGL TVEADAGCVV LVKDADKAET VVYISDPTNG SSPINLGIET PAVKGRRLVT
YQSEAPYQGR SMKFVVNENT PASTGRDVLA DRSAWTITTS LAGPADATVG GDDPKNIIDD
STVTSFLFVK PGKTFSGIEA PADYIPSFTI DMQTPQEMEY FVYRHRDYSN TTASLRANRI
SFYGKNNEAD EFTPVLENIT LDTSVAENKI LLPNKVSFRY IKVTITDYDK INSSTIQVSD
FNIGKKTLMD IPESGDPTGI TEVKAGNSDF TVSVYPNPVK QGEQVQIIAG NTQGIEFKLY
DTTGSVRAQG NTTTIDTNSL SQGIYILHVT DKAAGQRATA KFIVH
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