ID   U7PMH7_SPOS1            Unreviewed;       335 AA.
AC   U7PMH7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Dihydrodipicolinate synthase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1624_07672 {ECO:0000313|EMBL:ERS96136.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS96136.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
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DR   EMBL; KI440851; ERS96136.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PMH7; -.
DR   STRING; 1391915.U7PMH7; -.
DR   eggNOG; ENOG502QWNS; Eukaryota.
DR   HOGENOM; CLU_049343_0_2_1; -.
DR   OrthoDB; 1780992at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   PANTHER; PTHR12128:SF24; DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920); 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   ACT_SITE        155
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        184
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         240
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   335 AA;  34116 MW;  E3012CACC2CE0361 CRC64;
     MVRSLVPGIY APTQTFFMST TGSDSSETPN SLDAATIAKH AVRLVRAGCM GLVCNGSNGE
     AALLDGDERA DVVAITRRAL DAAGFASVPI IAGTSANSVR GTLRLCSDAA TAGADAVLIL
     SPTFVGGGSG GMGPAGIERF FALVADASPL PVVLYNYPAA AGGFDLDSDA LVRLAQHKNI
     VGTKFTCGSV GKMARVIGDL PATVSDVSLA ASPSSSPYFA FSGVADCILP AVVVGGTGAI
     VGAANVVPRA CVEVYNLAVQ GDLPKARAAQ QALAKADWSL TKRAIPGFKA VLDHYHGYGG
     APRLPIAPIA QDAADELCSE IADYMKYEQS LPDVI
//