ID U7PZA3_SPOS1 Unreviewed; 597 AA.
AC U7PZA3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Magnesium transporter {ECO:0000256|RuleBase:RU366042};
GN ORFNames=HMPREF1624_03434 {ECO:0000313|EMBL:ERT00065.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT00065.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|RuleBase:RU366042}; Multi-pass membrane
CC protein {ECO:0000256|RuleBase:RU366042}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765, ECO:0000256|RuleBase:RU366042}.
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DR EMBL; KI440844; ERT00065.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PZA3; -.
DR eggNOG; KOG2662; Eukaryota.
DR HOGENOM; CLU_025144_2_0_1; -.
DR OrthoDB; 73031at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015693; P:magnesium ion transport; IEA:UniProt.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR Gene3D; 2.40.128.330; -; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890:SF26; MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13890; RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU366042};
KW Magnesium {ECO:0000256|RuleBase:RU366042};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366042};
KW Mitochondrion {ECO:0000256|RuleBase:RU366042};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU366042};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366042};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366042};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366042}.
FT TRANSMEM 471..489
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366042"
FT TRANSMEM 501..523
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366042"
FT REGION 30..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 66239 MW; 524A3FB5C7559FE3 CRC64;
MLASPVRLQP APSAGLLRFL RHQSELLFVT DDNSNGGSNS KKRLSRVPSA SRKNSTTHCV
SETAVPVLQA SLIDLDTLIP KTLRARWRPA TTPVPPIPRK PLNKMALLAT PFSTSQPVQA
FPWRRSDKRQ KRAVGSPVAR ASWYDRAMDW HWAWHWRNSG PRDCADTQVG GSAGGRRSSL
LPGDLPDHGA GAEFASVMFN ARRLQTAKAA LEPRLRCTEV DEYGEVILVD GEFKKTELIA
KYGLLPRDLR KIDSSNLPHI LVRPAAILLN LLHLKVLIKA DRVLLFDVYG SKTSYPQSAF
MYDLQGRLQQ KQAPGAAGGL PYEFRALEAV LLSVTSELEA DFDTVREPIL RILSELEADI
TRDKLRVLLV LSKKVSTFEQ KAKLVRDAIE ELLEADDDLA AMYLTEKKHD LFRGEDDHTE
VEMLLESYHK ICDEVAQEAG SLVSSIRNTE EIVRAILDAN RNALMLLDLK FSIGTLGLAM
GTFLAGLYGM NLENFIEETN WGFGSVTGIS FAFSLLVCWY GLVKLRKVQR VKMHGPSTAS
GSGGAAMTTA DWANSFAALP PGVTSAGFAN APLDARSRER LRRLGMVREV LMRKKYY
//
