ID   U7Q128_SPOS1            Unreviewed;       451 AA.
AC   U7Q128;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1624_01947 {ECO:0000313|EMBL:ERT00715.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT00715.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
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DR   EMBL; KI440843; ERT00715.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7Q128; -.
DR   STRING; 1391915.U7Q128; -.
DR   eggNOG; KOG0409; Eukaryota.
DR   HOGENOM; CLU_035117_1_2_1; -.
DR   OrthoDB; 1121581at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 2.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   DOMAIN          6..159
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          182..303
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   DOMAIN          322..438
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
SQ   SEQUENCE   451 AA;  45885 MW;  3EC8E50884883D60 CRC64;
     MAAKPDVAFI GLGAMGFGMA THLVKQGYAV TGFDVWQPTL DKFAAAGGQT ATTPAAAVAG
     KSVCVCMVAT AQQAQQVLVE GDAAAAAALP QNAVILLCST VPCGYVQSLA ATLADPQGPV
     RRPDLLLVDC PVSGGAARAA DGTLSIMAGA SPDALANAAG RTVLADLADP TRLYYLVGGG
     IGAGSNTKMV HQVLAANQIL SGPEAMGLAV RLGLPANTAT LEALLQSPGR SWMFGHRGPR
     MVDGFQPLAS AVNIIVKDTA IITSEARRAA FPTHMTSVVE NVLYTAVNRG FGGKDDSQLL
     ELYTDGVPPP TANAASPDAS LRLVTNLLKG IHLVSAAESL AFAHHVGLDL DLVLDLCINA
     AGGSAMLETH GPGIVAVLRN EPAPPPKGDA SAATESLGDI YNNLAQAVDA AQAIKAPIHL
     GTQALNLLRL ALRKSGSESV PAAAAVNVWL R
//