ID   U7Q4M2_SPOS1            Unreviewed;       752 AA.
AC   U7Q4M2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Protection of telomeres protein 1 ssDNA-binding domain-containing protein {ECO:0000259|Pfam:PF16686};
GN   ORFNames=HMPREF1624_01147 {ECO:0000313|EMBL:ERT02844.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT02844.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC       {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the telombin family.
CC       {ECO:0000256|ARBA:ARBA00008442}.
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DR   EMBL; KI440842; ERT02844.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7Q4M2; -.
DR   STRING; 1391915.U7Q4M2; -.
DR   eggNOG; KOG4757; Eukaryota.
DR   HOGENOM; CLU_016663_0_0_1; -.
DR   OrthoDB; 1421338at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR028389; POT1.
DR   InterPro; IPR032042; POT1PC.
DR   PANTHER; PTHR14513; PROTECTION OF TELOMERES 1; 1.
DR   PANTHER; PTHR14513:SF0; PROTECTION OF TELOMERES PROTEIN 1; 1.
DR   Pfam; PF16686; POT1PC; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   DOMAIN          173..344
FT                   /note="Protection of telomeres protein 1 ssDNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16686"
FT   REGION          345..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..626
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..684
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  85127 MW;  7E47E9127F9C339D CRC64;
     MKATSALDAA LNFQDMSDVI NGNCKPYSIV SVQDYKMTVK LVDKSLETIN NTLHLHIFQA
     DVKAMPTFNL ADVVVVKRTK VQKAMGSDNF SLLSNFATII DVYRARTASP GKLEHHHQWL
     DQPNRVQYLT PSSLEHGFAE YLHKTINKNA LPSIQCFEAE AEKSRHILDK RRELKDVADG
     MFQDIIVNVV ADPYHTGSCS LLWVTDYTEN CNFRNVDDSG VSLNEYHQVG DQNKYLTKFG
     GRETHQVNPR TLSNWCGPAG RFSMLVTCYA EHASIVSKEV KRGSWVELKN VHVRWYGGML
     EGVMHEDLEY PERIKVRTLE IVNGEADEMD PRLQNALGRK KAFMKARQRN RKRKALPVAD
     GPETGKIPNA RQRRKLTRSA KPAQSTSSDV PLTNRPNEAI HCEYPDRALT SLSSMLDPKL
     YTVPGPEKLQ LPFANIKFKT KVRVVDFVPT NLADFAVKRY ISDIDMVKDD SDSDSLSEDD
     DRGNGAHCVW EWRFALCLED ASSARNDNDN DKEDNSSGLP PTRCWVFVDN FHGQMLLRSE
     ASDLRATKEA TRNLREKMFH MWGNLEEIKA DAKRRAKFTV EATNIRTKAA AQQKEDLEKA
     ARVAAKKRDR EEQKKQAARQ YHETNRKEIA FNGGNMKHYK QPEDDSDDDE DDNGGGGGAE
     ANNAMNTGNS NDATQAPVQT PGLSPDQVAR LTEIARELEK PVAQLTNRPF VCCLQQYGVR
     NTVYDNVEDE EDDECEYTWQ RTFGMFGTTI RG
//