ID   U7Q7Y5_SPOS1            Unreviewed;       962 AA.
AC   U7Q7Y5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   28-JUN-2023, entry version 36.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=HMPREF1624_01169 {ECO:0000313|EMBL:ERT02866.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT02866.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the XPO2/CSE1 family.
CC       {ECO:0000256|ARBA:ARBA00008669}.
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DR   EMBL; KI440842; ERT02866.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7Q7Y5; -.
DR   STRING; 1391915.U7Q7Y5; -.
DR   eggNOG; KOG1992; Eukaryota.
DR   HOGENOM; CLU_009614_0_0_1; -.
DR   OrthoDB; 178772at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR005043; XPO2_C.
DR   InterPro; IPR013713; XPO2_central.
DR   PANTHER; PTHR10997:SF8; EXPORTIN-2; 1.
DR   PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR   Pfam; PF03378; CAS_CSE1; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   DOMAIN          24..97
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   962 AA;  108291 MW;  536092B67D1B8BAF CRC64;
     MSAQIGHIVQ LLDSTLDPQQ HRKAESALRK EEEKPQFCLL LLQITSSQPL PLKTRLAAAL
     CFKNFIRRNY IDEDGNYKLP DEDISMIKKE LVGLMISSPA SIQTQLGEAI SIIADSDFWE
     RWDTLVDDLV SRLSVSDAKV TFGVLEVAHS IFVRWRPLFR SNELFTEINH VLSRFGEPFM
     TMLTVADQQI ESNKSNAEAL KGWFEVLSLL IRILYDLSCQ DLPPVVESNM QPVTALLQKY
     LSYSNPVLAA DDDDEATAVE NVKADICEVL QLYSTKYDDD FGPHTEPFIN TVWNVLSTTG
     PEKRYDILVS KALQFLTAVA SSARHAANFN SEETLGKIVE AVILPNVALR ESDIEMFEDE
     PIEFIRRDLE GSDTDSRRRA ATDFLRKLLE KYEMLVTQVV FRYIDHYLEQ GKTDWKAKDT
     AIYLFLAIAA KGAVTAAQGV KTVNQYVNVV DFFQKNVAAD LLSGSDTQPI AKVDAIKYLH
     NFRSQLTKDQ WQAAFQPLIQ NLASANYVVY TYAAIAVERV LFLTNDEGVH LFSREDIQPF
     AKDLLSHLFS LIEKDTAPAK LQENEFLMRC IVRVLIVIKE GVVPIVDDIL THLINITNVI
     RANPSNPRFY YYHFEAIGAL VRYSSSAIGD KLEARLWEPF SSILKEDVSE FVPYVFQIFS
     ALLETSPNLA LPEHYKTLIP VLLNDTIWET RGNVPACARF LSVILPKIKD AIVAENQILP
     LLEIFGRLFA SKKTEQNALD ILESVVISIP PASLDTYFST ILGKLFTKLD KGLTDSFKIR
     FVRFYHLVSA RGVENGLGAD YFVQHANKVT AGVDLFKPIY LNFVLPTTGQ FARPVDRKLG
     VISYTKTLCD STSFANLYEK GWGLTCNYLL DLLKNPPQVT SGVGDDVINE ADVDDIGFGV
     GYTPLNTCKR GPRDDFPEVE NVQQWVAAFF KEADRRHNGA IAQCVEKRLQ PEAKAALAPY
     LA
//