ID UL24_HHV7J Reviewed; 239 AA.
AC P52386;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=Protein UL24 homolog;
GN Name=U49;
OS Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Roseolovirus;
OC Roseolovirus humanbeta7; Human betaherpesvirus 7.
OX NCBI_TaxID=57278;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA Nicholas J.;
RT "Determination and analysis of the complete nucleotide sequence of human
RT herpesvirus.";
RL J. Virol. 70:5975-5989(1996).
CC -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC role in the dispersal of several host nucleolar proteins including
CC NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC impact on nuclear egress, UL24 supposedly acts on this process through
CC its effect on host nucleoli (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC {ECO:0000250}. Host nucleus, host nucleolus {ECO:0000250}. Host Golgi
CC apparatus {ECO:0000250}.
CC -!- INDUCTION: Expressed late in the infection cycle.
CC -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR EMBL; U43400; AAC54711.1; -; Genomic_DNA.
DR PIR; T41951; T41951.
DR RefSeq; YP_073789.1; NC_001716.2.
DR SMR; P52386; -.
DR DNASU; 3289507; -.
DR GeneID; 3289507; -.
DR KEGG; vg:3289507; -.
DR Proteomes; UP000009246; Genome.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR InterPro; IPR002580; Herpes_UL24.
DR Pfam; PF01646; Herpes_UL24; 1.
PE 2: Evidence at transcript level;
KW Host cytoplasm; Host Golgi apparatus; Host nucleus; Late protein;
KW Reference proteome; Virion.
FT CHAIN 1..239
FT /note="Protein UL24 homolog"
FT /id="PRO_0000115987"
FT REGION 212..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 28569 MW; F4EBC038679BE6B0 CRC64;
MSLEYLPPVR RRIGQYNHLR IYKKILLLKS NFEKLNFFLG NLFPEELHDS KIHVYFEVRL
GCRIPDCIIV FRHFGEKLLK TFHCYFFEFK TTFAKSNLFS IQKNRTQKIQ YLQGLRQLRQ
ATDYLQQFVI KNESLCKVNP VICFFRQHGL KLDFVKTFIA KELQLSSTFL CNLFTKYQND
TVKSILSISN PTNFRRACQK YSNLYRGRYA TTPKLGNSKT SKRKRRNSKK QDFKKLVKN
//
