ID UVRC_LISMH Reviewed; 603 AA.
AC B8DHZ8;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=LMHCC_1419;
OS Listeria monocytogenes serotype 4a (strain HCC23).
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=552536;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HCC23;
RX PubMed=21602330; DOI=10.1128/jb.05236-11;
RA Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M.,
RA Lawrence M.L.;
RT "Genome sequence of lineage III Listeria monocytogenes strain HCC23.";
RL J. Bacteriol. 193:3679-3680(2011).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP001175; ACK39764.1; -; Genomic_DNA.
DR RefSeq; WP_012581489.1; NC_011660.1.
DR AlphaFoldDB; B8DHZ8; -.
DR SMR; B8DHZ8; -.
DR KEGG; lmh:LMHCC_1419; -.
DR HOGENOM; CLU_014841_3_2_9; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW SOS response.
FT CHAIN 1..603
FT /note="UvrABC system protein C"
FT /id="PRO_1000200592"
FT DOMAIN 15..92
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 197..232
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 603 AA; 69318 MW; 8C9B70B4F58EAD30 CRC64;
MSSEHIQNKL ALLPDQPGCY LMKDRQGTII YVGKAKILKN RVRSYFSGTH DSKTQRLVQE
IVDFEYIVTS SNVEALLLEI NLIKKHDPRF NIRLKDDKTY PFIKITNERH PRLIITRQVK
KDKGKYFGPY PNVYAANEVK RILDRLYPLR KCSTLPNKVC LYYHLGQCLA PCVFDVEASK
YKEMQDEIVA FLNGGYKTVK NDLMKKMQEA AENMEFEKAG EFRDQINAIE TTMEKQKMTM
NDFVDRDVFG YAIDKGWMCV QVFFIRQGKL IERDVSQFPF YNDADEDFLT FIGQFYQKAN
HIPPKEIYLP DDVDSEAVQA VVPDTKIIVP QRGNKKDLVK LAYKNAKISL NEKFMLLERN
EERTVGAVER LGEAMGIPTP SRVEAFDNSN IHGTDPVSAM VTFLDGKPSK NDYRKYKIKT
VEGPDDYATM REVIRRRYWR VLKEGLPMPD LILIDGGKGQ IDSAKDVLTN ELGLDIPVAG
LAKDDKHRTS QLLFGDPLEI VPLERNSQEF YLLQRMQDEV HRFAITFHRQ LRSKTGFQSI
LDGIPGVGPG RKKKLLKHFG SMKKLKEASV EEIKEAGVPL NVAEEVHKHI TAFNEKAKNT
EQK
//
