ID V2GI61_9BURK Unreviewed; 692 AA.
AC V2GI61;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:ESH93053.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:ESH93053.1};
GN ORFNames=B551_0221185 {ECO:0000313|EMBL:ESH93053.1};
OS Cupriavidus sp. HPC(L).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1217418 {ECO:0000313|EMBL:ESH93053.1, ECO:0000313|Proteomes:UP000053474};
RN [1] {ECO:0000313|EMBL:ESH93053.1, ECO:0000313|Proteomes:UP000053474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HPC(L) {ECO:0000313|Proteomes:UP000053474};
RA Purohit H.J., Agarwal L.;
RT "Cupriavidus a Desert isolate.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESH93053.1}.
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DR EMBL; AMPR02000433; ESH93053.1; -; Genomic_DNA.
DR RefSeq; WP_023264908.1; NZ_AMPR02000433.1.
DR AlphaFoldDB; V2GI61; -.
DR OrthoDB; 9766486at2; -.
DR Proteomes; UP000053474; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ESH93053.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053474}.
FT DOMAIN 41..96
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 113..457
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 692 AA; 76224 MW; EE9C35EFD96A54D2 CRC64;
MTTLEEGKLV WTPSPAVRER ARLTQFMEWL RDERALAFDD YDSLWRWSVT EIEAFWDAIR
AYFDVRFDTP ARQVLARREM PGARWFEGAT LNYVEQVFRH AGEGPARQRA AIRHAGEAQP
LAELSWDALE AQVAALAHTL RQLGVERGDR VAGYLPNIPQ TIVAFLATAS VGAVWSGCAP
DMGQVAVIDR FRQIEPKVLI AVDGYRYGGK TYDRAPVVAQ LVDALPSLTD LIVVPLLGTP
DEMLPAAPAT APATAPATAP ATSSGTANAL RRHRWHGALA HQVPLQIDSV PFDHPLWIVY
SSGTTGMPKP IVHGHGGIVI EQLKLMAFHN DLGPDDVFHW YSSSGWIMWN AQVAGLLLGT
TIAIYDGNPA WPDAGVLWRF AEQAGITVFG AGAAFFTGGI KAGVVPSREA DLSRLRGIGS
TGSPLPAEAY DWIYRNVRDD IWLAPMSGGT DFAGSFVAGC PLLPVYAGEM QCRCLGAKVE
AFDEAGHARI DEVGELVCTE PMPSMPLYLW GDADGKRYRD SYFDTYPGVW RHGDWIKITS
RGGAIIYGRS DATINRHGIR MGTSELYRVV EELPEVLDSM VVDLEYLGRD SYMPLFVVLR
EGIALDDRLA DTIRARIREA LSSRHVPNAI LQVPGIPRTL SGKKMEVPIK KLLLGHDPDK
IANRDAMANP DTLDWYFEYA RRYLSESSAA TA
//
