ID V3P4I7_9ENTR Unreviewed; 588 AA.
AC V3P4I7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:ESN13868.1};
GN ORFNames=L370_04151 {ECO:0000313|EMBL:ESN13868.1};
OS Enterobacter sp. MGH 24.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX NCBI_TaxID=1329828 {ECO:0000313|EMBL:ESN13868.1, ECO:0000313|Proteomes:UP000017624};
RN [1] {ECO:0000313|EMBL:ESN13868.1, ECO:0000313|Proteomes:UP000017624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGH 24 {ECO:0000313|EMBL:ESN13868.1,
RC ECO:0000313|Proteomes:UP000017624};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Murphy C., Cosimi L., Cerqueira G., Feldgarden M., Hung D., Onderdonk A.B.,
RA Ferraro M.J., Hooper D., Dekker J., O'Brien T., Huang S., Quan V.,
RA Ernst C., Delaney M., DuBois A., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterobacter cloacae complex MGH 24.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESN13868.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYJG01000004; ESN13868.1; -; Genomic_DNA.
DR RefSeq; WP_023336229.1; NZ_KI535657.1.
DR AlphaFoldDB; V3P4I7; -.
DR PATRIC; fig|1329828.3.peg.4084; -.
DR HOGENOM; CLU_011781_2_1_6; -.
DR Proteomes; UP000017624; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 2.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ESN13868.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000313|EMBL:ESN13868.1}.
FT DOMAIN 7..132
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 304..521
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 527..585
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 588 AA; 65425 MW; FDF861537968A70B CRC64;
MSSTSPISAL RHWLEASHLD GMIVPRADAW QSEYCAPYDE KLAWLTGFDG SAGVALVLKD
KALLFVDGRY QVQARVQVNT NEVEIHHLHN EPLAEWLAEN VEAGTRIGFD ALLMTNSEFE
QLSATPCELV PLKDSPFDAL WTDRPAAPAG LIREMPVEHS GERSAEKRQR VAAVLAEHNA
DFLAVTLPDN IAWLLNVRGS DIPFSPVPLS FALLSRDGSV EWFVNDNKLS ALPDDVRSAF
TVAPQETFIE RCQQIAEGKR VMIDADSAPV ALRFAVEPRG EIVWRTDPIT LMKATKNPVE
LAGYRECHHQ DGAAWVNFLA WLSREVPLRE AAGQPLTELD AQAQQLAFRQ QQPGFIEQSF
ATISASSSNA AMCHYHSSEA SNKPIGHDHF YLNDSGGQYV NGTTDATRTL AWGEVDPQRR
LHYTAVLRGF LSLITLQFPS GTQGHQLDAF ARRPLWEMGL DYDHGTGHGV GHQLLIHENP
HRIAKKVNPW PLVAGNIMTI EPGYYLGDSH GIRIENQVEI VESRPGFCKF ASLTLIPIDL
SQVELHLLSD QEKQWLDAYH QQVREALLPL VNSDARAWLE EATAPMSI
//
