ID V3PQJ4_9ENTR Unreviewed; 327 AA.
AC V3PQJ4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Zinc transport protein ZntB {ECO:0000256|HAMAP-Rule:MF_01565};
GN Name=zntB {ECO:0000256|HAMAP-Rule:MF_01565};
GN ORFNames=L370_03743 {ECO:0000313|EMBL:ESN13466.1};
OS Enterobacter sp. MGH 24.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX NCBI_TaxID=1329828 {ECO:0000313|EMBL:ESN13466.1, ECO:0000313|Proteomes:UP000017624};
RN [1] {ECO:0000313|EMBL:ESN13466.1, ECO:0000313|Proteomes:UP000017624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGH 24 {ECO:0000313|EMBL:ESN13466.1,
RC ECO:0000313|Proteomes:UP000017624};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Murphy C., Cosimi L., Cerqueira G., Feldgarden M., Hung D., Onderdonk A.B.,
RA Ferraro M.J., Hooper D., Dekker J., O'Brien T., Huang S., Quan V.,
RA Ernst C., Delaney M., DuBois A., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterobacter cloacae complex MGH 24.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Zinc transporter. Acts as a Zn(2+):proton symporter, which
CC likely mediates zinc ion uptake. {ECO:0000256|HAMAP-Rule:MF_01565}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in);
CC Xref=Rhea:RHEA:71195, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01565};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_01565}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01565}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765, ECO:0000256|HAMAP-
CC Rule:MF_01565}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESN13466.1}.
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DR EMBL; AYJG01000004; ESN13466.1; -; Genomic_DNA.
DR RefSeq; WP_023335899.1; NZ_KI535657.1.
DR AlphaFoldDB; V3PQJ4; -.
DR PATRIC; fig|1329828.3.peg.3679; -.
DR HOGENOM; CLU_007127_2_0_6; -.
DR Proteomes; UP000017624; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd12833; ZntB-like_1; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR HAMAP; MF_01565; ZntB; 1.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR023714; Zn_transp_ZntB.
DR PANTHER; PTHR46494; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR PANTHER; PTHR46494:SF3; ZINC TRANSPORT PROTEIN ZNTB; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519, ECO:0000256|HAMAP-
KW Rule:MF_01565};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01565}; Ion transport {ECO:0000256|HAMAP-Rule:MF_01565};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01565};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01565};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01565}; Transport {ECO:0000256|HAMAP-Rule:MF_01565};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_01565}.
FT TRANSMEM 268..289
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01565"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01565"
SQ SEQUENCE 327 AA; 36677 MW; B1DBD34F46C5BEC7 CRC64;
MESIKGSELN VPDAVFAWVL DGRGGARPLE DNDVIDSAHP CWLHLNYTHP DSADWLASTP
LLPNNVRDAL AGESLRPRVS RMGDGTLITL RCINGSTDER PDQLVAMRVY MDDGLIVSTR
QRKVLALDDI VNDLKEGTGP VDCGSWLVDV CDALTDHASE FIEELHDKII DLEDNLLDQQ
IPPRGFLALL RKQLIVMRRY MTPQRDVYAR LASERLAWMN DDQRRRMQDI ADRLGRGLDE
IDSCIARTAV MADEIAQVMQ ESLARRTYTM SLMAMVFLPS TFLTGLFGVN LGGIPGGAYR
YGFTAFCVML VVLIGGVAWW LHRSKWL
//
