ID V3Z9P5_LOTGI Unreviewed; 1813 AA.
AC V3Z9P5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=HELP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_166239 {ECO:0000313|EMBL:ESO87658.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO87658.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO87658.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; KB202849; ESO87658.1; -; Genomic_DNA.
DR RefSeq; XP_009061556.1; XM_009063308.1.
DR STRING; 225164.V3Z9P5; -.
DR EnsemblMetazoa; LotgiT166239; LotgiP166239; LotgiG166239.
DR GeneID; 20240290; -.
DR KEGG; lgi:LOTGIDRAFT_166239; -.
DR CTD; 20240290; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR OMA; MEGAKMQ; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 3.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 7.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 4..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 330..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 381..461
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 559..592
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 664..712
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 965..1006
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 982..1062
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 1049..1091
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1262..1308
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1539..1580
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1590..1663
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 1621..1662
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1778..1813
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1216..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1813 AA; 201470 MW; 870F2A9580CCC2FC CRC64;
MADKTAPQSQ LKLEWVYGYR GHQCRNNLYY TSNKDVVYFV AGVGIVYSVR DHKQRFFLGH
DDDIISLTLH PEKTLVATGQ IGKKPYICVW DAATCETVSI LKDGHEHGVA AMGFDKEGSR
LVSVGLDQHS TINVWDWRKG KILATVRGHS DKVFDVQFHP YMDNTIVSCG VKHIKFWTLC
GNALTPKKGI FGKIGEIQTI LCLAFGPGNI TYSGTLAGDV YVWKDNTLDS VIQGAHNGAI
YTLDMCDEGY TTGGKDSMVK LWDTDFKPIS AVNLANSQDG YKGLCVRSVC WRADRLLVGT
QDSEIFEIDV KDKNKPQCLV QGHAEGELWA LAVHPRKPIF ATASDDQTLR LWNMTNSELL
SKTTLENKIR SCSFDFDGNQ IAVGFTDGSF MVLRSRDLSE VIHMKDRKEV IHEMKFSPCG
KFLAVASNDN FVDIYSVDQR FKRVGTCSGS SSFITHIDWS EDSKYLQTNS GASERLFFKM
PVGKQATNKE EIMSIHWASF TGVLGAEVSG IWEKYTDTND VNAVDANFAA QTVVTGDDFG
LVKLFRFPCL KKGAKFRKYT GHSAHVSNVR FSSDKQKVIS IGGADHAIFQ WKFYPQGSGS
DDLSLGGVDA YLDSNSEASD SDLSDVGELD SDLEREKQVS YDRAIYKEDT KSLKKLMRQD
MKAGDKRKKG PIDSLKLSYI HGYRGYDCRN NLFYTQSGEI VYHVAATGIV YSKEKNQQKF
YTCHTDDILC LCIHPLKDLV ATGQDRSSSY WTGDGKKLVS VGLDDNHTIV VWDWKKGEKL
ASTRGHKDKI FVVKWNPFDG SKLVSVGVKH IKFWTQTGGG FTSNRGTLGK VAKLCDMLCV
AYGKSDDLCF SGGSDGNVFI WQGLNLQKVV KAHEGPVFSM HSLDKGFVTG GKDGVVGLWD
DQFDRCLKTY ALKRAAIAQG SRGMLIQESP AIRAIVLGHG KILVGTKNGE IIEVDKSGPM
TLLTQGHMEG EVWGIDCHPT QAIYATVSDD KTLRLWDLAT DHRMLNFKEL KQAARCVAFS
PDGKALAVGQ KDGSFVVVNA ESMDDIIHIH HRKEEISDIR FSPDTGKYLA VASHDNFVDI
YNVQSTKRVG TCKGASSYIT HIDWGSNGKV LMVNSGAKEQ LFFEAPRGHR ITMKSNDIEK
FNWDSWTCVL GTACEGIWPP KSDVTDVNST TDDFGFVKLF AFPYQQNYYM CCYDSDVERE
KKMDYTSKIY ISPIREKEGV KPHNQEQAQS TQNKPVASRN VNKAPLVQKA DLPPSTGGKR
RKITPVNELQ LEYVHGYRGF DARSNLYYCN DANDVVFHAA GAGIVQNMST GSQSFYLEHT
DDIICLDVNQ HPKFKNVIAT GQIGNQPSVH VWDAVTKKTL SIIRGVHSKG VCSVDFSCTG
KLLLSVGLED DHNLAVWRWQ DGTYLKSIYM TFVFISEYLN SLTYTGALSG DVYVWKENTL
IRLVQKAHTG PVFSMFTTLR DGLIVTGGKE LPRSKDNGPV KLWDQDMKRC KAFPIRDEGK
RADVVKSVCR SKGKILVGTR DNSVLELSEK EGNIQILVAG HSEGEVWGLD THPTLNHFIT
ASFDGTVRMW DIAKKTLLAR LEVGSARSVA FSPDGELIAV GLNNGEFLVL SVNGLKLWGK
KRDRSGAIND VKFSPDNKYL AVGSEDKCVD FYNLTEGPSL NRSSFCKGIP SFVIQMDFSA
DSKYIRVGTG DYTPHVFKVP AGTLVEDKQI LDNITWASWT SVLGEEVIGI WPRDSSNADV
NCAHLSHLGS SLATGDDNGF VKLFEFPCSD RYASHKNYVG HSAHVTNVRF SSDDRHLIST
GGDDCCVFVW KCV
//
