ID   V3ZIQ4_LOTGI            Unreviewed;       532 AA.
AC   V3ZIQ4;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   ORFNames=LOTGIDRAFT_108452 {ECO:0000313|EMBL:ESO84112.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO84112.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO84112.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR   EMBL; KB203566; ESO84112.1; -; Genomic_DNA.
DR   RefSeq; XP_009065239.1; XM_009066991.1.
DR   AlphaFoldDB; V3ZIQ4; -.
DR   STRING; 225164.V3ZIQ4; -.
DR   EnsemblMetazoa; LotgiT108452; LotgiP108452; LotgiG108452.
DR   GeneID; 20230354; -.
DR   KEGG; lgi:LOTGIDRAFT_108452; -.
DR   CTD; 20230354; -.
DR   HOGENOM; CLU_018084_6_0_1; -.
DR   OMA; EMIQMLY; -.
DR   OrthoDB; 916229at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 2.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT   DOMAIN          1..58
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          120..163
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          163..205
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          53..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  59442 MW;  D2CA567788619E54 CRC64;
     MTDPVGNANH RLKSYKNLAL DSSELRRRRE EEGIQIRKQK RDQQLFKRRN VSMPAPGEDM
     TVSDVQENTV SSSSAVRITP EMVQALYSDN TEEQEVATQK FRKLLSREPN PPIDEVIHTG
     MVPKFVEFLQ RDGSWSLQFE AAWALTNIAS GTSQQTRIVL EAGAVPIFIR LLSSDIEDVQ
     EQAVWALGNI AGDSPECRDY VLNEGILVPL LQLLSKSTSL SMTRNAVWCL SNLCRGKNPP
     PDFVKVSPAL PVLARLLFHT DKDVLADACW ALSYLSDGPN EKIQAVIDSG VCRRLVELLM
     HTNQSVVAAA LRVVGNIVTG DDCQTQVILN CSALPCLLHL LGNSKETIRK EACWTISNIT
     AGNRVQIQAV IDANIFPVLI DILGKAEFKT RKEAAWAITN ATSGGYPEQI RYVHYQGCIP
     PLCDLLTVMD SKIVQVALNG LENILRLGEQ DKKNTNNLNS YAVLVEECYG LDKIEFLQSH
     ENREIYQKAF DIIDRYFSSE EEDKAIAPQV DENNQQFQFG TPQNAPMGEF MF
//