ID   V3ZS10_LOTGI            Unreviewed;      1086 AA.
AC   V3ZS10;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   03-MAY-2023, entry version 42.
DE   RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN   ORFNames=LOTGIDRAFT_232470 {ECO:0000313|EMBL:ESO94223.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO94223.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO94223.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
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DR   EMBL; KB201847; ESO94223.1; -; Genomic_DNA.
DR   RefSeq; XP_009055068.1; XM_009056820.1.
DR   AlphaFoldDB; V3ZS10; -.
DR   STRING; 225164.V3ZS10; -.
DR   EnsemblMetazoa; LotgiT232470; LotgiP232470; LotgiG232470.
DR   GeneID; 20248933; -.
DR   KEGG; lgi:LOTGIDRAFT_232470; -.
DR   CTD; 20248933; -.
DR   HOGENOM; CLU_285334_0_0_1; -.
DR   OMA; HESEWEN; -.
DR   OrthoDB; 2900795at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   CDD; cd11770; SH3_Nephrocystin; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR039687; NPHP1.
DR   InterPro; IPR030642; NPHP1_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15176; NEPHROCYSTIN; 1.
DR   PANTHER; PTHR15176:SF1; NEPHROCYSTIN-1; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          534..594
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          104..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..151
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..250
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..296
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..335
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..364
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..387
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..526
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1086 AA;  124544 MW;  5947543B74A00055 CRC64;
     MPKTDASPLS IVQKQAEVTK KAVEKLVKEC NKVIKDKKLK DKDVKQKQLF KECFQLKKDV
     LSVHDRAEKL TKEDEPKKVK NYDNKKDFEV KRLANLQNQL TMIMPKLAPE EDEEAFTKEL
     KEAGEISDTP VNEEEEEEEE SEEEDEADNA VTQENQGEIK DSPKDEKKGK DKEKKGKDKH
     KKDKDKKGKD KDKKKKDKDD KEEDEDEDDE EADDKDAKAK DKKNKDKKDG KSKDKKEKDK
     KDKKKKNEVD EEEEDDEEDK KKSKDKKKDK DKKEKDKVEK KNKKEKVEAP RQEVKDLEEE
     SDEEEEDEEE EDEDIEEAIE GDDEEDFEET EDEEEDHAVV KSVRKQDAKQ VQAKTSPKDE
     TDYVETMEYV DEESEEEEDS DDDDVEDMIQ PEKAKVIAST PKPASRTLTP KSESSKTASS
     TTVLPSSSSE NKTESSNIVS SASQSKTPQP ASRSSTSKAS SSSSKEVSKI ESKKDEADHE
     DDEEDEDESE EEEEEEEEGE VEEESEEEDD EDEEEEESDE EDTTKAEDTL EVTQGIERFV
     AIDDFEAVEK GDLSVKKDEV IRIIEVREDG WWIAENDAGK QGLVPKTYLK VYNQYSSLQQ
     HDEEEKKEHS EEEGEEKQDG EKTPHSKRRS GRELWGSLKK TVNETLVTDV LHAMGAGPPG
     FRLPTLSKYF NESEKFRMKN FLSPKLSESN LGYRDLLFNP ATGEMRAVEV RLERVITITS
     CQQIPPPATG IIVQRRYVRM CLFDGQNVLS NIHTIRVAAE DKTERNWSFN SKISDLMDVQ
     LHNEFFIRSN STNSNIGVLF ELCISCVKSK SEERGEFSCG WVHLPLTDKT GVPIANKNYD
     LYVHGGTPYE RDVEVDPSVS RREFIKFNLL NKGSRRYSSS NALVSLISGN KQPRLLVKVS
     VPNKEQKTQL DLLPEILVGD MCLLPFYTYY RQILADALII KRLDLDSTEV IHSPFLRQFP
     KVADNPDLMS LFRETWVNKL KAVKRAEKRD VEAMKGLLDK VFKESVYPVI TTGNFVPYKT
     GNTEIEMKRK NVIEKFSQIK RERKSALAAL LASDIVYTPF DMSEVTFNII NPYSLADKFI
     PIPVES
//