ID V3ZXE5_LOTGI Unreviewed; 342 AA.
AC V3ZXE5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Caspase family p20 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_228989 {ECO:0000313|EMBL:ESO89052.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO89052.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO89052.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR EMBL; KB202619; ESO89052.1; -; Genomic_DNA.
DR RefSeq; XP_009060096.1; XM_009061848.1.
DR AlphaFoldDB; V3ZXE5; -.
DR STRING; 225164.V3ZXE5; -.
DR EnsemblMetazoa; LotgiT228989; LotgiP228989; LotgiG228989.
DR GeneID; 20247857; -.
DR KEGG; lgi:LOTGIDRAFT_228989; -.
DR CTD; 20247857; -.
DR HOGENOM; CLU_036904_2_1_1; -.
DR OMA; ENSHHEY; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.30.70.1470; Caspase-like; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR47901:SF8; CASPASE-3; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 67..199
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 244..337
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..28
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 39189 MW; 3356607F33D391C2 CRC64;
MAEERIESFD ETNWMVSDEE GDVDSSDSEF EDREGKVVDI SVCEEVKQKL KEHYSENSHH
EYEHYNGKNL MIVIQNKDFH ESRQRHGSTA DVENLKKTFK RLGFIVKTFK NLSGEKMDVK
LRKARQKFNH KDASCFACVI LSHGNQYETG DYERKDSVLG VDEQAISIEY VMKIFNNDNC
PDLMGKPRLF FIQACRGKGY DKGAETLVPV EDSSNSNVEQ ISSELEETYI EATSGDYSPP
VTTFTYPTPC YSDSMVMFAS PPGYAAYARK GGSIFVSCLC DEFQIYNRKH NFFQILSRVA
NQMALDFETS NVVEDTDYEK CKIVPCIHSC LTRDVKFQIL DD
//
