ID V4A1W1_LOTGI Unreviewed; 536 AA.
AC V4A1W1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=WD repeat-containing protein 76 {ECO:0000256|ARBA:ARBA00021234};
GN ORFNames=LOTGIDRAFT_228373 {ECO:0000313|EMBL:ESO97818.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO97818.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO97818.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC that it acts as a specific reader of 5hmC.
CC {ECO:0000256|ARBA:ARBA00002530}.
CC -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family.
CC {ECO:0000256|ARBA:ARBA00005434}.
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DR EMBL; KB201304; ESO97818.1; -; Genomic_DNA.
DR RefSeq; XP_009051663.1; XM_009053415.1.
DR AlphaFoldDB; V4A1W1; -.
DR STRING; 225164.V4A1W1; -.
DR EnsemblMetazoa; LotgiT228373; LotgiP228373; LotgiG228373.
DR GeneID; 20247637; -.
DR KEGG; lgi:LOTGIDRAFT_228373; -.
DR CTD; 20247637; -.
DR HOGENOM; CLU_017019_0_0_1; -.
DR OMA; DTVVRHN; -.
DR OrthoDB; 3679036at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14773; UNCHARACTERIZED; 1.
DR PANTHER; PTHR14773:SF0; WD REPEAT-CONTAINING PROTEIN 76; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 360..401
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 60965 MW; 2452DA5C7438F67E CRC64;
MKSAVRSSKR KRESVEMDKT KSKTKRFKDE VIEDLELPAV SKSIEFDPSP RKDEIQVKNE
NIKPDSLDED SNDEEEDEDY ELVRQRNIEA NNKFLSQIGM FEAKQQLSSA VKPKKESSQR
GIKKPKKIRE PIVIRKSRRL ARIDPEGNHL PDPVVLEYNK PIMPPVCPVD MSAILLNDDD
QDYHKKVSSI FTSTKIPEQK PLSSALQSYL KEINNLKLEE TGIAKVVPTR VFSLAIHPMV
DKLLIAAGGK WGGVGLWDVD STDNQDGVVA YKPYVSPVNW VSFHQDYPAH IYTTSYDGSC
RYADFETGKF LEIYAVPSDE NILLRNADFL TSETLLISQS DGCVALVDRR TPSTTAENIY
EVHERPLRTL NIHPDKQYFC TASLDATVKV WDIRQMKVKK NTCISEGKHS RVVNSANFSP
ITGKHCVSLS DDNTIHIYDV DANKQLKLKK SIRHNNHTGR WLTKLRCIWH PRREDLFISG
SMERPRRIEM FSDEGTLVKT FSNEDYLGSV CSINAFHPSL NILAGANSSG RVHVFR
//
