ID V4AHM2_LOTGI Unreviewed; 440 AA.
AC V4AHM2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=LOTGIDRAFT_150028 {ECO:0000313|EMBL:ESO96417.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO96417.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO96417.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
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DR EMBL; KB201459; ESO96417.1; -; Genomic_DNA.
DR RefSeq; XP_009052782.1; XM_009054534.1.
DR AlphaFoldDB; V4AHM2; -.
DR STRING; 225164.V4AHM2; -.
DR EnsemblMetazoa; LotgiT150028; LotgiP150028; LotgiG150028.
DR GeneID; 20235499; -.
DR KEGG; lgi:LOTGIDRAFT_150028; -.
DR CTD; 20235499; -.
DR HOGENOM; CLU_013387_5_0_1; -.
DR OMA; CKDVFEP; -.
DR OrthoDB; 203742at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR PANTHER; PTHR45867:SF3; ACID PHOSPHATASE TYPE 7; 1.
DR PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361203};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT CHAIN 18..440
FT /note="Purple acid phosphatase"
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT /id="PRO_5005148354"
FT DOMAIN 25..117
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 127..332
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 357..419
FT /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
SQ SEQUENCE 440 AA; 50552 MW; E43096712FC0E8D6 CRC64;
MELALFSLLI LINLTNSKKI GVFEPQQVHI ALGVTIDKIS VTWSTRYDTV ESIVVYGIDN
LESGNETIGT SSKFVDATGK NVQYLHHVTL SGLKPATKYT YICGSKGQWS PVYTFTTMKA
GNDWSPRFVF YGDLGFINSQ SVPRLDKDIQ NGMYDVALHV GDFAYNLDTY SGTTGDNFMN
IIQPVAANLP YMTCPGNHEF ANNFTQYKRR FFMPGDENGD RMYYSFNVGP IHIISFSTEY
FFDINYGIMQ IPRMFEWLKN DLRKATINRN EQPWIVTMAH RPMYCSNDDR DDCTHHESLV
RVGVPILHIF GLEDLFNEYG VDLMLWAHEH SYERLWPIYN REVYNGSRQY PYTNPGAPVH
IITGSAGCQE NIDPFDKDRP YWSAKRIPDY GYTRMAVINR THLYMEQVSD SKGGSVADQM
WLIKEKHGPY PTAMKFRQVP
//
