ID V4AJC1_LOTGI Unreviewed; 531 AA.
AC V4AJC1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN ORFNames=LOTGIDRAFT_170979 {ECO:0000313|EMBL:ESP04279.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP04279.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP04279.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU361242}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|RuleBase:RU361242}.
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DR EMBL; KB199835; ESP04279.1; -; Genomic_DNA.
DR RefSeq; XP_009045089.1; XM_009046841.1.
DR AlphaFoldDB; V4AJC1; -.
DR STRING; 225164.V4AJC1; -.
DR EnsemblMetazoa; LotgiT170979; LotgiP170979; LotgiG170979.
DR GeneID; 20241607; -.
DR KEGG; lgi:LOTGIDRAFT_170979; -.
DR CTD; 20241607; -.
DR HOGENOM; CLU_013477_0_1_1; -.
DR OrthoDB; 202750at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR027791; Galactosyl_T_C.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF131; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED; 1.
DR Pfam; PF02709; Glyco_transf_7C; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|RuleBase:RU361242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242}.
FT DOMAIN 402..517
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 531 AA; 61676 MW; 49E7752DEDD2207A CRC64;
MLQRRFMLKF GVTVICVWTM LAMKLTFDTS VPSFQDPMAG ILLKKKQLRE NVGYFVGKRR
EIFWPFLKLQ PNYTEVKEVY GVDLNTIGEN GKGLSIDTRR LSKKEQKKVD TGYVRYAIKE
YVGNLVSVRR NLPDPRIQDC KDISYPKDLP KTSIIMCFHD EAWTSLLRSV HSIIDRTPPR
LVEEIILVDD NSTYGWLEPL LEPIMKNPRT VTMPTINTID SKTFAVNTDR LEQVGIFTFP
ILRFSWMKTP ERIDRDRSSP ADYIQSPTMA GGLFSISKVF FNHIGTYDNQ LDIWGGENIE
ISVKIWMCGG SILISPCSHV AHIFKARLPY VGGYHVMLRN LGRVANVWFD DYKYKFINQK
GNIDPFGDIS ERVKLREKLQ CNDFEWYRRN IFPEMYFPGS GVHYGNIQSV ADPNLCIDGA
KLKRSEPIIP YPCHSNESQQ WDYTEAMQIR IKDLCLDFSG ATFRAEGCGP HDAQNWKYQD
KKIINRVTGQ CIGLSKDGSK LQIQKCDYRL FQLWNWKKVR EPFIPDFYKY L
//
