ID V4AQM2_LOTGI Unreviewed; 347 AA.
AC V4AQM2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Lipase domain-containing protein {ECO:0000259|Pfam:PF00151};
GN ORFNames=LOTGIDRAFT_226820 {ECO:0000313|EMBL:ESO97125.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO97125.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO97125.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB201334; ESO97125.1; -; Genomic_DNA.
DR RefSeq; XP_009052198.1; XM_009053950.1.
DR AlphaFoldDB; V4AQM2; -.
DR STRING; 225164.V4AQM2; -.
DR ESTHER; lotgi-v4aqm2; Pancreatic_lipase.
DR EnsemblMetazoa; LotgiT226820; LotgiP226820; LotgiG226820.
DR GeneID; 20247366; -.
DR KEGG; lgi:LOTGIDRAFT_226820; -.
DR CTD; 20247366; -.
DR HOGENOM; CLU_027171_0_0_1; -.
DR OMA; HARSHAY; -.
DR OrthoDB; 5392146at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR002331; Lipase_panc.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610:SF178; FI22312P1; 1.
DR PANTHER; PTHR11610; LIPASE; 1.
DR Pfam; PF00151; Lipase; 1.
DR PRINTS; PR00823; PANCLIPASE.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..347
FT /note="Lipase domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004717064"
FT DOMAIN 23..346
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
SQ SEQUENCE 347 AA; 37776 MW; 3919B369B0F84E9C CRC64;
MLLKLSLVLV VILPAKAWLF GSEKCYGSYG CFANSKPYNN AKGNVPDSPE HQNIQFLLYT
RHNAHTAQVL KPHDHGSIQK SHFKHHAKTF LIVHGYTDNG KTNWIKTMTA ELLKKEDANV
IAVDWQTGAA QVNYFQAAAN TRVVGAVAAQ LIKDVHSVGQ TPYSKFHIIG HSLGSHIAGY
AGERVHGLGR ITGLDPAGLC FEKFDIKTRL DPSDASYVDV IHTDAETLFQ LAFGMAKAIG
HTDYYPNGGK NQPGCPHIGN HALDLITGKI TQLSGGVSCS HMRAVEFFIS SINSHCKFNS
QPCTSASLFS SGHCRSCGHG CSQMGYHSSS HDRGSYYLAT TSHSPYC
//
