ID   V4AZA5_LOTGI            Unreviewed;      1235 AA.
AC   V4AZA5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   13-SEP-2023, entry version 30.
DE   RecName: Full=HEAT repeat-containing protein 4 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LOTGIDRAFT_238549 {ECO:0000313|EMBL:ESP00441.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP00441.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESP00441.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
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DR   EMBL; KB200702; ESP00441.1; -; Genomic_DNA.
DR   RefSeq; XP_009048889.1; XM_009050641.1.
DR   AlphaFoldDB; V4AZA5; -.
DR   STRING; 225164.V4AZA5; -.
DR   EnsemblMetazoa; LotgiT238549; LotgiP238549; LotgiG238549.
DR   GeneID; 20250786; -.
DR   KEGG; lgi:LOTGIDRAFT_238549; -.
DR   CTD; 20250786; -.
DR   HOGENOM; CLU_007256_0_0_1; -.
DR   OMA; GHEENSH; -.
DR   OrthoDB; 2909690at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR12697:SF20; HEAT REPEAT-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR12697; PBS LYASE HEAT-LIKE PROTEIN; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT   REGION          154..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1039..1123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1039..1078
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1079..1123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1235 AA;  139776 MW;  02AA4032A6F4B525 CRC64;
     MEGVSAPLHF PCAAHVKMPQ IGSDESDITV VKSNVLHHNS MSSIQRSQYS DMGEKQVLLR
     PFGKTYIKDI CGDLSFTEDV VRDRCFHMLP YSDKYFYEAL DVSSLIPKQP KRNILIGRHN
     TSGSDKRHMP CIPTKTQYLK PLRKKISDKA LEMHQEAVEK QRSESQASLN TLDSQDDPVF
     LTEVDDKQSK STKLPKINKD KHVELSHEAE EGNEKKHDWD AYLMSIISPL TANWIVHQKM
     TGVGGVTSEK EELSKLLEGW YGKPEHTDLI RDDISDTDPV TTPTAEKHKK KVWKKEESIL
     LEKVLQNNEE EPKARDPYSD NNEAPFYRQP VGFRKQKKKI EKEELGAINS TARDIEVKTY
     KPPPPPTLRD YFNPKAGETL IQTDNVFERE WLTGNEQVYQ GESDSQQIVM ANQNKYIKQL
     QIAYPDVEKW CPRNEENQED TEQFIIPSKG ARRWKSLPKP VDDTRDVLKC LPPGTEPVPV
     IPSDAKTKKV KQQNPALSQI IDEWRSKWQL SGQFADSNPH DLLRDMADIQ PHVRLKAIAT
     VAKSTEYKAP EEDGILLEYQ DQQIDAVSRL PEFLFDALNC LLEDKHEQVK KAAAVTLYTL
     NKPSDKAEAV LRELLLSESP SDRWTAAQCL AHFGVCDSDV AGEVITQLLA TEDSIKHEQC
     KQLLAKMSAS TTLIHSMVAE QLNSSSWRHR VIACKIFPAL DGTINKDIAN KLAHLMWKDW
     HVEVRKVAAQ TLGKTGHGRS VHDDLKEKIQ GSDERLKQEA ISRIGHLGIM TAKLLPVILD
     CFDDEYNSVR MEVCITCGNL MIQDQQVIDK LLYLATFDTV WKVKALAMQA LGKIGVSSPA
     IKECLTWALR YEKEGGVRAE ACHTLTTLEY TGDDFIEILQ ERLLVEEEAI VRNEISKALN
     LLGISSSDDI DTVAQIKCEV RKLCDQGTIA SMILSNDKNE EKQRNMSRMI YQAKQEIQKL
     FSRTNTYLRM NSKSEIDGNL ELYALKQEED EVFKGQKTLG SPRSVRINTD HQSQQESRLT
     LLMDKEVHSI IYQTIVETSS PDSGTRASSV STDIYGMEEV SDSSSPRPLT SISTRSKSHM
     GRITEENEDD SKLDFNETKS EIDLKSEFDM ESQSDESIDD KSKHTTEIGL EDITDDIPSS
     RIDHGHKSPY AQSFGDLGSS ALSLGGSARR RQIMSRETIR EKERINAEAR KSLMSLNVRY
     SSMMEGLKTL DEGFSADKCK NIPAETEKII SNISI
//