ID V4B0S6_LOTGI Unreviewed; 2306 AA.
AC V4B0S6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Transformation/transcription domain-associated protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_140419 {ECO:0000313|EMBL:ESP00831.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP00831.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP00831.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR EMBL; KB200650; ESP00831.1; -; Genomic_DNA.
DR RefSeq; XP_009048459.1; XM_009050211.1.
DR STRING; 225164.V4B0S6; -.
DR EnsemblMetazoa; LotgiT140419; LotgiP140419; LotgiG140419.
DR GeneID; 20234312; -.
DR KEGG; lgi:LOTGIDRAFT_140419; -.
DR CTD; 20234312; -.
DR HOGENOM; CLU_000129_1_1_1; -.
DR OMA; RLWEEQW; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1218..1725
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1953..2274
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2274..2306
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESP00831.1"
SQ SEQUENCE 2306 AA; 263987 MW; AE0CE232F97BC7B0 CRC64;
TYLEPLTTLV LRGEKALLLE AGSPFRQPLL KFLLRYPTQT VELFLSEAAL KDQQWTRFLE
FMIKHKDGGS IRQVLKSNST RLINVTSGQI PVRNPSLRLF LVAFAMVFVT IKVIMIFLFQ
YMVERIHNNY ALQIVANSFL ANSTTSATFA TILDSMDFKH WKEPALLVKC LLTFFKYNTN
EIELLFNILR CFTHRYIPQF QFVKDFLDKT VTKYDVEWKR NAFFKFVYVF HLQTWPQDLK
AKILQMILIP SFQASFENGD GDKLIGGPPA PEQDNEENII SVFINRIIDP DNPFATSDAV
RILLLQFSSL LVEQASPHIH DAANKKQGNK LRRLMTFAWP CLVTRGCVDP ATKYHGHLLL
AHIIAKFAIH KRIVLQVFHS LLKAHALEAK SVVRQALEII TPAMPGRMED GNGKLTHWTK
KIIVEEGHSL GQLVHILHLV VRHYKVYYPV RHHLIQHMVN SLQRLGFSTT SSIEYRKLAV
DLAEVIIKWE LQRIKEEQET NETGDIDVTQ TVIINQSVKR TASVDSPQDP KRARHTSGIA
DSPHVRYLFR SQRSSSDLNK PIDKIYCDGV VNFLLRIACQ VNEASVTIGS AGELLSKRCI
QYLKNVLRPE VWPNVDLKLN WFDKLLTTVE NQQPNFANIC TALELLTFLL SILKKETILS
SFKPLQRGIA ACMTCPNSKV IRAVHSLLSR LMSHFPTEPV TSNVASKYDE LECLYGCVCK
VVYEGLTNYE KQSSGLPSQL FSTLMILKAA CLHNQCYIDR LITTFMKVLH KMAREHLTPS
TPETSPASEL LILSLDLVKN RVGVMSIEMR KSFIGQILVG LIEKTPDAKV VKAITKMVED
WIKIKTQIQI NQSPSIREKA ILLMKLMQNV EKRFPDDSDL NGQFLDLVNY IYRDETLSGS
ELTSKLESAF LAGLRCNQPA IRQKFVEVFE NSMPRKIFDR LLYITCSQNW EAMGSHFWLK
QCIELLISVA VNGLSIQSSS PMNLLPSANS VVNMADSQDR AIFANITHLK EEPMDVESVD
SNKEEDDIDM ELTGVSSDEV LNKENDKKEY GDPKQSLQTQ LQRQAKFLEN CREVKTLQYL
NALSQLCHQN TQLSHITWLE LFPRIWKILT EKQQQTLSSE LVAFLCSGSH GVQKECQPSS
VHTFVEGLSS CVPTISIRPC VLKYLGKTHN LWHRACLQLE QMTIENGPLT QIKTRPVSEY
EFEPTSNQHQ VYFNSSSLSQ SQGAVVAQEK PALKYKQVFT LILTFLSLSG ILLAMGKARQ
DLNSNPLSPG VVPEFRLWEE QWIKCSKELN QWNHLLEYSK SKENNNPHLV LECAWRVPDW
NLMKTAHAKV ELTCPKDMIW KVNLYRGYIA ICHPEDNHIN MIERLVEFAS NYAIKEWRRL
PSVVSNIHIP LLQAAQQIME LQEAAQINQG LQPGNITRSS SVHDMKAIVK TWKNRLPMIS
DDISHWSDIF TWRQHHFQFI KNHYDTNPTP DTSIGASSNS MLGIHASAQA IIHFGKIARK
NGLTGVCLDT LNRIHTIPSV PIVDCFQKIR QQVKCYLQMA GVMGKSELQE GLEVIESTNL
RYFTKEMQAE FYALKGMFLA QINRSDDANK AFSSAVQMHD TLVRAWALWG DYLENIFSRD
KNIQQGEYAI TCYLHACRHQ NEGKSRKYLA RVLWLLTYDD EKLTLATAVD KHCVGVPAIQ
WLPWIPQLLT CLVRNEGRLI MNLLSQVGRM YPQAVYFPIR TLYLTLKIEQ RERCDNVSSD
GGPIKAPAPM WRCSKIMHMQ RDMHPTILSS LEGIVDQMVW FRENWYEEVL RQLRQGLAKC
HAVAFENRTA VTDATITPHT LNFVKKLVST FGVGIENVSS VSSTFSSAAS ESLARRAQAT
AQDPVFQKMK SQFTTDFDFN VPGSKKLHNL INKLKKWIKI LEAKTKLLPK SFLIEEKCRF
LSNFSLSLVE VELPGEFLLP KHSHYYVRIA RFMPRVEIVQ KHNTAARRLY IRGHNGKIYP
YLVVNDACLT ESRREERVLQ LLRMLNHFLM KQKETCRRLL YITVPRVIAV SPQMRLVEDN
PASISLLDIY KSRCRATEHD APIARYYERL ATVQARGSQA SHQVLRDVLK DVQNNMVPKG
LFKEWALHTF LNATDYWTFR KTMTIQLALM GFSEFILYLS RMNPDMMYLH QDCGFLNISY
FKFDLDDHTG ELDANRPVPF RLTPNITEFI TTMGVNGPLT ACMVAIARCF VQPQYKLPSF
LRAILRDEFI TWHKKREEET NAGVEPVDME GSQLITMVNK AVQAITTRLQ NLATFDGAES
RVSTLVAAAV SHDNLCRMDP AWHPWL
//
