ID V4BBX4_LOTGI Unreviewed; 357 AA.
AC V4BBX4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0000259|Pfam:PF00149};
GN ORFNames=LOTGIDRAFT_237661 {ECO:0000313|EMBL:ESP03562.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP03562.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP03562.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB199981; ESP03562.1; -; Genomic_DNA.
DR RefSeq; XP_009045792.1; XM_009047544.1.
DR AlphaFoldDB; V4BBX4; -.
DR STRING; 225164.V4BBX4; -.
DR EnsemblMetazoa; LotgiT237661; LotgiP237661; LotgiG237661.
DR GeneID; 20250515; -.
DR KEGG; lgi:LOTGIDRAFT_237661; -.
DR CTD; 20250515; -.
DR HOGENOM; CLU_069901_0_0_1; -.
DR OMA; DRYLAWY; -.
DR OrthoDB; 5387988at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR033308; PGAP5/Cdc1/Ted1.
DR PANTHER; PTHR13315; METALLO PHOSPHOESTERASE RELATED; 1.
DR PANTHER; PTHR13315:SF4; METALLOPHOSPHOESTERASE, ISOFORM E; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 327..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..246
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 357 AA; 42330 MW; 0D3215F74F60E0AB CRC64;
MKSKMDVYYY RKVKNKMVCV LLVIVMCLLL YNECVVFWYQ QLIWPPLPEN SDRNLVVLLV
ADPQIQGEYL EPMFPIGSIS RWDADRYLKK TFERVYLYSQ PDIVMFLGDL MDEGDQATHE
QYDTYYNRFM DIFQLAKQSK VQFIAGDNDI GGEKIHKRIP DKVNRFERYF QPTYGSTQVS
FLDIIKFDYW LYSKWGTAPL LANMRNKSSS FKMVITHESI LKTNNNKMQL IRDIKPDVII
SAHMHQSMQY EGNLRFGDMQ VNSIKLNQIN TFINVNVSNP TSVNEVMVPT CSYRMGEPRM
GYGLAVLSDD KTMKYTVLWS PSRYRSLRLY IYVVIIIFLF YNFKKWYQAW VNCKTYF
//
