ID V4BFV4_LOTGI Unreviewed; 662 AA.
AC V4BFV4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=TBC1 domain family member 23 {ECO:0000256|ARBA:ARBA00014207};
GN ORFNames=LOTGIDRAFT_229906 {ECO:0000313|EMBL:ESP04792.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP04792.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP04792.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
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DR EMBL; KB199651; ESP04792.1; -; Genomic_DNA.
DR RefSeq; XP_009044301.1; XM_009046053.1.
DR AlphaFoldDB; V4BFV4; -.
DR STRING; 225164.V4BFV4; -.
DR EnsemblMetazoa; LotgiT229906; LotgiP229906; LotgiG229906.
DR GeneID; 20248142; -.
DR KEGG; lgi:LOTGIDRAFT_229906; -.
DR CTD; 20248142; -.
DR HOGENOM; CLU_026555_0_0_1; -.
DR OMA; ITPEQYC; -.
DR OrthoDB; 91822at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd20788; TBC1D23_C-like; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR039755; TBC1D23.
DR InterPro; IPR045799; TBC1D23_C.
DR PANTHER; PTHR13297:SF5; TBC1 DOMAIN FAMILY MEMBER 23; 1.
DR PANTHER; PTHR13297; UNCHARACTERIZED; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF19430; TBC1D23_C; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 21..202
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 314..422
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
SQ SEQUENCE 662 AA; 74844 MW; 867B00EBC94D4128 CRC64;
MDFKAQNSTI TASRNICKGR PVPEHLRAEI WQICLNVEGK ADSISSFDGF FDMAEQSLLR
SDCTALVDKL GNDEEDKVSV VSDLESIITF YCKSRNVKYS TNNGWLDILQ PLLSLKLSKA
ELYNCFYAIV AKYIPQDCVK NGKPFHLFRL LLQYHDPEIA SYLDTKRITP DSYIKNWFTS
LFASACDLKV ITKMWDVYFQ HSDPFLIFFM SLVILVNARD IILLSDESKP NLIETMSMFP
SGLEADDIED FCALAQYYYN KTPQSFKWDY QSILFGNKLI QGKSSLVDQA SQALCLPVSI
SELLEANQQA VTEESVRYFV VDCRPAEQYN NGHLSTAFHL DANLMLQNPV EFNTAVHALF
AAQQMAIAAG SVAGGEHLCF MGSGREEEDQ YVFMVIAHFL QKGHQYICSC QGGFAALHEK
LKDNLSNEIA DHNAKRCIVC NPDSTSSTSE LDNTDDFKDS GKDSSLFGKL SNVMKSKSAE
YKEKLTNYIK NDQISGERHV SNTDKVGKRY RNMASVFTIG DDEEGEEGSY GGSSDDEPRE
VVSLETWLHK PDLIYHCKCK EIKANGYMYP SYMLIVNSHL YLLREIPKEK NMVYIQSRRA
LGSIVKITSK KRHPELITFK YGTSEDDGLK ITDMDRFLIP TAGDAMRIVK SQIMKVLDAL
DS
//
