ID V4CGL6_LOTGI Unreviewed; 526 AA.
AC V4CGL6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESP01235.1};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_157404 {ECO:0000313|EMBL:ESP01235.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP01235.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP01235.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
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DR EMBL; KB200521; ESP01235.1; -; Genomic_DNA.
DR RefSeq; XP_009047869.1; XM_009049621.1.
DR AlphaFoldDB; V4CGL6; -.
DR STRING; 225164.V4CGL6; -.
DR EnsemblMetazoa; LotgiT157404; LotgiP157404; LotgiG157404.
DR GeneID; 20237355; -.
DR KEGG; lgi:LOTGIDRAFT_157404; -.
DR CTD; 20237355; -.
DR HOGENOM; CLU_518371_0_0_1; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20830; C1_PIK3R-like_rpt2; 1.
DR CDD; cd00159; RhoGAP; 1.
DR CDD; cd09487; SAM_superfamily; 1.
DR Gene3D; 3.30.60.20; -; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF5; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA; 1.
DR Pfam; PF00130; C1_1; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00109; C1; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 3..74
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 85..136
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 157..220
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 246..296
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 317..511
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT NON_TER 526
FT /evidence="ECO:0000313|EMBL:ESP01235.1"
SQ SEQUENCE 526 AA; 60491 MW; AE5060FC771ADA94 CRC64;
MDELFAIYEA VYPYFPQDHS HDDSHMTIRK GDRIKVSIPN SKFDLSEQDW LNGSNLASGS
RGFFPASYVK YIETQGNQQA RPPRPHRWVE SYVSRPVLCH HCGDYIWSLR DKIKECEGCG
KCYHNICFSL IGNSQCTTYD GLTKPEVYLH PVSVENWTVK NVIEWMAALN LYRYIETFRE
ANICGEQLRE MDEEKLREMG IKDEFHQKSI LVCIDELCGQ NTESQPYAAR LPPVISIDME
ASGCSEHRFA EYNFSSMQRC HLCDKFLYGL VHQGLQCREC GLCCHRFCST SQPTECNVPK
LERIRRPSFS HNSVFGQDLP DEVNKSQKDA PDVLHVFVQE IEQWCQEHST EALSVYRISC
KAEEINQVKK IFCQEGDTSK VNLSSFSVHC VAGALKKYLR ELPNPVLPVE MYNMFIHTAK
SKSSTLKSLS DLIEELPPAH KSTLQFLMAH FCRLWKIQNE SGVSDGLDKL SHVFCHILLR
PPWERIIEIV DNTKLHIDIF EELMRNGNWG EDIPPIPTSV PPTLPP
//
