ID V4YQX3_TOXGV Unreviewed; 4204 AA.
AC V4YQX3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=ATPase family associated with various cellular activities (AAA) domain-containing protein {ECO:0000313|EMBL:ESS30654.1};
GN ORFNames=TGVEG_286932 {ECO:0000313|EMBL:ESS30654.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS30654.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS30654.1}.
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DR EMBL; AAYL02000231; ESS30654.1; -; Genomic_DNA.
DR STRING; 432359.V4YQX3; -.
DR EnsemblProtists; ESS30654; ESS30654; TGVEG_286932.
DR VEuPathDB; ToxoDB:TGVEG_286932; -.
DR eggNOG; KOG3595; Eukaryota.
DR OMA; CIVINCS; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 2.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT DOMAIN 1224..1379
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1521..1656
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1980..2128
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 267..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1882..1917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2306..2330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2602..2625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3610..3632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3911..3949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2694..2721
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2903..2951
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1892..1906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2610..2625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3610..3629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4204 AA; 467386 MW; F0A608C5FA323841 CRC64;
MREVRFRLCA SILQKNLFSL DGVLRKALLS IRACGTKLAA CPRLLFHGEG ACALDLFLEL
QASRRQQLVA ELRKVWRTVT AEAQGESIQR RKKPETIHNS SLPMLLSPQL SRACSESLQS
FLEENGFPAR KKSAFESSGN SLDVPFTSRR GDAPLRIGQP DDCPAARLSR DASALSRGSR
ASGPPASYTV KATARLQCRK LAKFVKVTEY LLLDALLTFV KGSTARFAAS LEAFAKAEAL
PNASEASAPA AEQIEVPASP TAEWRGRHRA TRNEQNACRT ATDGSPPPSD KALFLLHLQI
DVNGLTVTPN KAAFRSAIET VLLENFKAVA TTPALTEAPQ VAAFVAEASL GEATEKNALL
FASFFPTNDT SFLDLVKRVG KTVDTLFNQV LQTAEQFSHL ACLYTRCEAT TLASFKENDL
AAFDDTLAQY LEKIEEISAM PQQLKVGAFC LDTSNVRKVL LPSLKRVVSV IQEHLPTLAG
RVMTTLLQAI KGATTKLGEV PTDIDSYVQF NAYLQEVKGS AFGEYEARCS FVSEIFDLVK
KFSVKVDAAL KAQFVELSQA LSTLRTQIQF AVSASEANTE RFFEELEAAI PEVEAKLSEV
HKQLDSVVFS TETADVDAVL AVLESLDNDV RAVTAKVERC RRCQEVLRTE TSAFVDFDEL
VHTFNALQTF FTAKKSWASL RIQWGNQAFA AADVHAIEAQ VQSCVKQLNR LQRTLGSNAA
FQSMQTDVLK FRSFLPVVVA LRSSALLPRH WEKIHGFFDE SLELQSSSLL LKDLLNADVT
PFVQDILQIA ADANAEKTLA AMLESVRETW ATLQLVTTVY KASKDKLPIL GSLDEVLAVL
DDSLATLATI SGSRAARPIQ ADIEFEHEKL LLFQETVEEW EVLQRNWLYL EPIFASADIR
KQLPSEAAKF AGVDQEWRAL MKETQEYSLA LAAGAKEGRL STFRRMNQVL DAIRKALEDY
LQHKREAFPR FYFLSSDELL EMLSQAKNLA AIQPLIRKCF ANIYDLGIQE EAKVTEIVSM
ISAEGEEVLF AKALKPRGSV EKWMPEVEEM MFCTVKRNLR SKHGEAALGR REWISDTPCQ
VAACVAQILW VAQTEEALAS NDVHSRLTQH YQRLGEQLQE LTEIVRDDLT MLERRTVSAL
AIQELHNRDV VAELIDARAE SCTHFTWTQQ LRHYWDGEQD ACVVEQMEAR FDYGNEFLGA
PTRLVVTPLT DRCWLTITSC LKLLKLSSSV AGPAGSGKTE TVKELARMLG YFCLVFNCSE
SVDLYILEKV FAGVAASGCW TCLDEFNRLD VDVLSVVAQQ LQTLRHCLLK EESRGLGAQV
RGDAKSGRDS FLSASRLTRV LPSSAIFITM NPGYAGRTEL PDNLKLLFRN VAMVVPDYTA
IAEILLFSEG FADAKRLAEK LIKLYKSCSE QLSQQAHYDF GLRSVKTVLL LAGELRRQDP
SANEESLLIR AICDANEPKF VEEDLPLFYS TLSDFFPSYC GEAESDEEFK DAYFAAVEER
GLQASASSLT ATRQLSQLLL ARMGTVLLGA PMSGKSTAIL LLADILSRLP AAGGGNEMYA
VYYRVVNPKA LSISALFGKV DSLTQEWSDG VAARMVREFA ATETGSPKWI VFDGPVDSLW
IESMNTALDD NQMLCLPNGE RIKLRPEMRL LFEVTDLQAA SPATISRCGM LHFPSRGVSW
ESLVRSWLNR LPHDPFTEEL REDLFEYFRL VVPATLTHFQ AETLESEIAS PLLSLVSSLC
NILQAVLHIP LDPAAEQRLE SDGPKDDRAF NAGRRRTTTT PFSEAASPRH SACCTALDIS
PDLLRLLLLP AFAFSFIWSF GGALKSRSSR FFGKLVEEFF QDRLALPRGD DVFDFALNFE
SVFGVSYSKF FSQTSLSREA CREGGGEQVN GPGSEEDREA LKRTRRSSGA GRTTFGETKF
GAGWEASELE KARKTLHAFL SWEAVVPAFS YDPRQPFFSL LVPTKEFARA AFLLDKMIEA
KKSVFLTGAV SSGKTTVVTH LLDEKRESGT LHTIRLCFSA RTKADEVQQT VESKLEKKRK
NQLSAPGGRE CVLFVDDVNL PLPEKTGTQP AIEFLRQFQE FKGFYDSKKI QWNVIEKCLL
LLGGAPPSSG RKPLPPRFCR HSLSLRLAEP DNVSTQKMFL GILTGYFEAE GVNADIRFAA
KPLVDATIEL YTQVKETFLP TPPRPVYVFS FRNMKTLFQG ILAAKKTSLP DKDALIRLWN
HEVCRTFYDR LMTDEDRQRF RTSLVSLVNR KFSLEWNETL LVYPSSRLWG NFVSPERLYE
EAPHPKQVLP ILETFRDELF ASGGATTAGA RNGDTADTGD AADSRSTGAG GRSAGSSLVF
FSEAVEHLFK LCRILMLARG NALLVGVGGT GKQTLFRLAA FIQETAVVEF VAATSFHSTC
SLEEDSPPPT TRTGEPQPTE TSVSVLDQFR ECEKSFLLQS GLSRCLPTAF LLTETQIVDD
GILQDINTLL STGEISSALD AETVDKIVED LLPLAKETRR DTSRDGLLQL FQERVALNLH
VVLSMSPAGS ALRERLRCFP ALLSCCSVVF FDSWSKESLS EVARDFFSAQ ASATQDAPAS
SSEVPFEDKV SGESESVWEE VQTASGENES LFEKRSRTAG EREDVEANSQ RRAYLCVQMH
QSAIETSKAF LSQLNRPVYV TPKCFLDLIG LVVKLKNERQ DALQRQRSLL SAGLTRLHRT
NAQVEKLREE LEQLKPVLET KKIESEQLLA TVESDRAAAC SEQERVAAER RLVMDQQQEV
SLLQSDAQKD VDTAMPALEA ALASLDALDK KDLTEMKSFA KPPPLVVATM EVVNLLLGEK
ADWDTARKVL SDSGLMTKLK NYDKDHISPG LLKKLDKLLQ RSDYTPEQVG KQSVAAMSLC
MWTLAIQTYA KVAREVQPKR EKLAAMNEML DRANAQLAEA EEKLSLVMAK VQAMEERLAT
LNAEKEKLLE ETTLCQQRLN RAGILTSGLA DEAARWKHTI SILNEQLVLV EGDAFLSAAS
ICYCGPFTGR FRGMLHASWT ELAKHSGIAC ADNFSLTEVL SDPIELRDWD LQGLPSDRTS
LESGVFVRSA VKLGRAPLVI DPQQQAKKWI KNRESENGLR VLDLSHPKLQ TILTSSVRVG
QPVLLEDVGE SLPPILDSVL LLPRVRTVGS NPKIKIGDKA VELDPNFSLF LSTKLANPHY
LPEVALKVLL VNFTVTPEGL EQQLLTEVVR LETPDTEKRG TEILVQITKD KRVLKQLEEL
ILQLLSETGG NILDDEKVVQ ALHRSRSTAE SVARRLQDAE SILEEVQVAR RFYSPVASRA
ALLYFVVASL SEVESMYQYS LEFFTLVFRE SLKRENADAA SVQARRESLL SAATHTLFAS
VARGLFHPHK LLFAFLLAVE ILKQERANFQ HDAWQMFLRG VSRVGEARVP ANPLPSLFSE
TEWRNVQFLE ENLEVFRGLC AHIEDHTEAW LLWIEGDMSL EASPFPFCGL SEEAKLLPQL
LLVKAIRSRQ VISAVQQLIV KVLGEAFVDF SPSRFQDIFA ATSHTTPLLF ILSPGVDPSS
SLFKFAREKG LPDNALHTVS LGRGQGPKAS RILEGAMRDG SWVLLQNCHL AKSWLPVLER
FVFSLSEAES SPSACSPPSS VSEVPQNKER DTPLSPKFRL FLTSMPAPYI PVAVLQNSLK
VTLEPPSGIR ANLKRSIMNT MQEDLDLFGR APEGVPGDVS GKADAWTRIR FALQFFHAVV
QGRRTFGALG WNVGHHFTDS DLDASLVLFK TLFRLQEKVE DFDFLPLQYL VGNINYGGCI
TDEWDRRCLT NLLSLYVSPE VVLEEDALSH LGLQRIPYAG SLEALNQYVE TLPVEDKPEL
FGLHPNATLR LHQERGASLI QTVLTIASRE NATVSAGGAR EDQTLQFALL MKQKLPPVLK
WRPVSAEIFE TPNGERPIPP GMAAPRRDHR RGKSSRLSGA GELVSDSEHP VKPESMAVFL
FQETERFNAL INLVGETLQQ LELAVKGLIS ITGELDEMHT CISNNQVPPQ WTAQAYPSLK
PLGSWFEDFL QRVAALRRWT ESEKPPVAFW LSGFFFPQGF LTAVLQNYAR KVSAPIDALG
FTFHVMSTCK PEELVEEDTL EDSCYVYGLY IDGARWNYHR EVIDDQLPGA THDVFPVIQF
QPGVRPAVLD ADYTCPVYKT MRRAGVLSST GHSTNFITAI DLPTDQHPSK WILRGTALIC
SVED
//
