ID V4ZRV3_TOXGV Unreviewed; 1385 AA.
AC V4ZRV3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=TGVEG_270450 {ECO:0000313|EMBL:ESS36231.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS36231.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS36231.1}.
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DR EMBL; AAYL02000011; ESS36231.1; -; Genomic_DNA.
DR STRING; 432359.V4ZRV3; -.
DR EnsemblProtists; ESS36231; ESS36231; TGVEG_270450.
DR VEuPathDB; ToxoDB:TGVEG_270450; -.
DR eggNOG; KOG0477; Eukaryota.
DR OMA; CCIDEFC; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT DOMAIN 898..1081
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 147041 MW; 5BE16C4BB527B523 CRC64;
MSRRNWSVLR EGRRPAYPPA GSPEGQASHP SPGKPLAVVS SSSSSSSSSS SSSSSSSSSS
SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSYVC
SPAVSQASSQ NTNCSDFCLP VVLASFLPSA ASSPPALPEF PCPLSRPVAG ARSSFAAFSA
AVLEASAASP QPWTRAAMDS LREAAPSQIR AEFLRFLATT PSHLFTLGLY VSAATNVSAK
SALFASLLSA QTPGGLSSSA AAFWRAVALD PQRRALHEMV STVSFEVDLL SLLHQAPLLG
AAVVNKPRET LAFLETDVVR DVAASLLRHM QSCGDHDMQS KEAEEKRQEE QLLLRSAPPL
KIRLTHIPKD KYMERRTPLQ IRTSDEGKLV VITGRVARAG DLQAVEEERT MSCRQCGECF
RVFACAEQGY QLDIPLKCPA GSAAIREQLR ARAASQEKVP QRGRGGFWGR RRGPCEGETF
DSLGEATCLM DYQEIKLRCS LAGARKYLSR DPAHRALLPV VLLRHLAGTV SMGDIVTVVG
IVGRRWQRVV RDMRAEVEMV LEANNIFHIR PDPLAASRRS VEWLFRDPYL VQVFAAHQRK
RLLSTDARKT FRPPSLQDTH PPPASSSSSL GSAGSQTERE SQSPRKLRQK LPSLEEVFQA
FWESTGRDTD AAHGEATGGA GERGRARERG EKGEEGLRGG SGGWDEWTAR GRLLDAACPS
LYGMGSAKLA LLLTLISGCE ARTVPPGGFG DTRALAANSF ASQEEGDQPE EESGSRWRKF
VRPAAGDAQR EADIWAPPTN RAAYLLWGGD AADGDDVKAE TSRSKAKREK ATGEQGEGEG
GRRGERDSRL HRQPDDRVAS EEDEGARCQD CRRPGRDDRE DGDVEGVRHR DAKRKREDRE
SGEGCSTRHK CHLLLLGATG TGKSTLLLAG RRLAQKAFGA TGMGCTAAGL TCAAVRDSGN
GAWHLDPGIL VLADEGVCCL DDLYLMKKDA QAAIHEAMEQ QSISVAKAGL VTRLTARCSI
IAATSTETGA VGGKTFSSLS RLFDANSPSG SSECYADLPC LDANMPPPLF SRFDAVVVLG
DAPRAIDAVT DFIVGRAVGR GQKSSAAGPL PPPLDVATHA SKTEIGSSSS LECSRAAQGR
RRPSALGALL SWTTSLLRLY LAFVGNTFFP GLSRQAGQVL SRYYLRLRAV GSSSGESRSA
GGALHALGPF GKPAGPHGGG TGVTVRFFEG LFRLTQAHAR LMARHTATRR DAIAVIWMLE
TSLCGNRVVP GLKKGNADVP EGRHGLLRLS EASTARVVDF LCVLPPQKNS GAYSAGPDEW
SRCPGGAENA GNRESTGQLV YPSLQTVAGK ALHCDIRSEA QYLAVEKLIL KNLGLSMESG
GAQQT
//
