ID   V5ALS5_TRYCR            Unreviewed;       303 AA.
AC   V5ALS5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS56179.1};
GN   ORFNames=TCDM_12499 {ECO:0000313|EMBL:ESS56179.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS56179.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS56179.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS56179.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS56179.1}.
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DR   EMBL; AYLP01000596; ESS56179.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5ALS5; -.
DR   EnsemblProtists; ESS56179; ESS56179; TCDM_12499.
DR   VEuPathDB; TriTrypDB:TCDM_12499; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   InterPro; IPR021287; Trans-sialidase_CS.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF11052; Tr-sialidase_C; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          214..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   303 AA;  31987 MW;  D593C2133B277A2D CRC64;
     MMVGRRRRIT ACSSRGVAQW PVGRQGENQL YHFANYNFTL VATVSIDGEP TEGNIPVMGV
     KMNDGDKKTV LVGLSYNNKE KKWILLCDGG ENKEHSSHWE PDTAHQVAIV LQNEKEGSVY
     VDGILLGNAQ LDLKDIKGSK GISHFYIGGD GGSAGTKEDV PVTVENVLLY NRPLTSEEIG
     AFNPNKAPIS PPEDLTAAVL VDTSSTVVSG SVAQKTVSVS TPGGSTVKHE SSASSGENEG
     TVGGTDGQKE EVQPQVREVN ATALNSSLVN SSQGNNSDGG IVRGSGLLPS LLLLLGLWVF
     AAL
//