ID V5ANR6_TRYCR Unreviewed; 860 AA.
AC V5ANR6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS62375.1};
GN ORFNames=TCDM_09964 {ECO:0000313|EMBL:ESS62375.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS62375.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS62375.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS62375.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS62375.1}.
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DR EMBL; AYLP01000188; ESS62375.1; -; Genomic_DNA.
DR AlphaFoldDB; V5ANR6; -.
DR EnsemblProtists; ESS62375; ESS62375; TCDM_09964.
DR VEuPathDB; TriTrypDB:TCDM_09964; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..860
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004730237"
FT DOMAIN 54..397
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 719..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 90312 MW; 2C0EEA02F13B3CE1 CRC64;
MSRRVFTSAV LLLVVVMMCC SACGAAQAAG QSTVSKFEWK DVKDEGVTVE SLGVPGLLNV
GSDVFAVAEA QCKKGETSVF TGIASQILTM EKSNEPKELL EDAKKDTQVL EEVTSGKGKK
VDVSRPTTVV DESDIYMLVG KHSHDAADNC QAGTENIKSG MLLVKVQVSG EADKKIDWKT
TDGVPCTLGE KHESWTGLIG GGGSGVKMND GTLAFPVEGT KKEEKYVKAA LLIICSSKEV
TCWKLSKGMS ADGCGVPSVV EWGEDKLMMM TACDGGRRRV YEIGDKGESW TEALGTLSRV
WGYPKGNERS EKGVRSGFIT ANIGDGVEDN RNVMLVTLPV YSNEKDNLKG VLHLWLTDNT
HIVDIGSVSE KDEDVTASSL LYKSGNDNNE KLIALYEKKG DADTPSLGMV SVLLTAQLEK
VKEVLKTWKE VDKRVSKLCP SIAAKDAPTD DACATDKITD GLVGFLSGNF SGTTWKDEYL
GVNAAVKKGA EEGAAEEKAE KAESSDGVNF QGAWAEWPVG SQGENQLYHF ANYNFTLVAT
VSIHKVPTKG DNPISLMGVM MDGDGDNGKT VLLGLSYNNE GNWAVLCGGT VTKDLSSTWD
TQRQYQVAIV LQNGTQGSVY VDGQPVSGDA QCELETTNSK EISHFYIGGD GGSAGGQGDV
SVTVTNVLLY NRPLSSEEIG ALNPNKAPIP SLEKNPLNPS TVSSGSVVSP APPVAANAQI
AGNPSTPAGT QLTEQGQSMG SSGAGSGGAS ASAVSTVSTP SAEEESVVQV TSGTSPDGTQ
TVGGGFTADG EPTMETREGG TNGQEEEVNT QDREVNTTAL SSSLGNVSQG NNSDAGTMRE
SGMVPSLLLL LLGLWGLAAL
//
