ID V5AW53_TRYCR Unreviewed; 814 AA.
AC V5AW53;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=TCDM_06651 {ECO:0000313|EMBL:ESS65025.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS65025.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS65025.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS65025.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS65025.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYLP01000073; ESS65025.1; -; Genomic_DNA.
DR EnsemblProtists; ESS65025; ESS65025; TCDM_06651.
DR VEuPathDB; TriTrypDB:TCDM_06651; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:ESS65025.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 814 AA; 89841 MW; 288390E8A884D60C CRC64;
MSLFIYFYTV FFSLCFSCKE LQATQQDSFK AARMAMRWVA APYLFFALLL LLALFSPQGA
ASQAAVTDTH VRLWLMRKMN QVRLKGTPLA FYSGMNASLW ARNCTVAEGV RVEIVEKEEV
QEGNIAILEE EIRKDKNVLA LVGKQSGEFL QLVLPLLKKY DLVSFAPFTG SSLVRGWNPN
LYFVRADPAA ELLALLRHAW THLRVHRLGF MYLQGVSFGD REYAQAQRVM LGMGYNLSGV
FTVKSSMSRG AKKEVFDAAW KAFAKTQPQA VIVFGPPIQD TVKFIKRMLT DYRTAGAYLL
APLMLQDFFL RAWQGAVAGG VELVPGQVIT TGTSPLAKDI QYAAIQRFQR VMRDYLAHSG
QKDYVDKDHF LKDDGDGAMM VAGWIAGEVL SQALGNREWV KNRTSFLTSL YNQRRYVVDD
IVIGDYGGEC KSEAASQGAT CLCNQGGRTV HIDRVMGAHR LKPFKGVMRF PLSNCNVSYV
KIPPVFIGLY LLMDDNIFAF TACLQFDVVF AAASSLHERW WEQGVLLLNF LQSNTYDSAG
DLRSELQSRR AHAVLGVVTD AMLDVEGMTF IDPLFLEPRL NRFRRNVIRL SPTLEQQFFV
IARYLGNTSG GSAHAVIRSG EAAAMAEVLR LSLETFGGSL LSTKLLAGGD KMADHLPAEG
EVFVVGISAD DVGAIARHVA SNDGVRVFVV FSEFALLHAE FVAAFRDCAG ADRVVFATSL
PHWNDENSTS ETTKKFVIAV PXXXXCAACA GAAAGVPAAR LGDERDRRRV PQVRGGPCWG
GRGVRAADRA PGRCCVPAEL ERPARASRCA HRAV
//