ID V5BDD7_TRYCR Unreviewed; 778 AA.
AC V5BDD7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=TCDM_05816 {ECO:0000313|EMBL:ESS65734.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS65734.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS65734.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS65734.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS65734.1}.
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DR EMBL; AYLP01000058; ESS65734.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BDD7; -.
DR EnsemblProtists; ESS65734; ESS65734; TCDM_05816.
DR VEuPathDB; TriTrypDB:TCDM_05816; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ESS65734.1};
KW Helicase {ECO:0000313|EMBL:ESS65734.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000313|EMBL:ESS65734.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 212..411
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 470..632
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 778 AA; 86899 MW; C600E4E5D41A8D53 CRC64;
MQCLFLEERV SAEGYVVLLA ETFRSSFQRI QFFLATIAEP TSRPSLMHEY RMTPFSLGAA
VSASIPVSDV ICFLDEYVYG FCDEGENSRR ARVCAFLEMC MSRYNLARIV IEGARTFVEC
DNVETAETLL LDPVVRSLCA EPPQIVPVVP HSLLVLRSRA VARRVAERCV LLGFPLQQQY
DYERDSGVRN INVMLKTQTK PRPYQIDAVN AAATEGSLRS GCIVLPCGAG KTLVGIMLLC
KVKKPTLILC AGGVSVEQWK NQILEFASIC AHDTDDEMAA AEKHRSRLEG AARIACLTGK
QKDPVTEETD IVLTTYSMLV TAHRAQMRQR AAHASGLAGD RHQKRRRANP KEKLFQPYGL
LIMDEVHVMP AEAYKESLSL VDAKGVVGLT ATYVREDAKI QDLFHLVGPK LYDVSWETLA
SSGYLANVTC IEVLTPLTRQ FGLEYMQRSG EDHTLQQRKM PLLVMLAAAN PNKMLCVLEL
VRRHVADSSK ILVFCDHLLL LREYGILLHA PVICGQTPHR ERLMIFSDFQ STSKLNVICL
SRVGDVSVNL PSANVVIQVS SHGGSRRQEA QRLGRILRPK ARASNGKMVD AWFYTIISTD
TLEMAYAAHR TAFLVDQGYI CRIIEFQPDE LSKDEVDDVA VAAETGDFVS LKQEKLRSAL
REKKLQCESL TVPQGSVDAR KIEYQLDLLS RVVSNWELEY HIQGLKQASS GHDGFPPDDD
ANASEGRDVM EIVPESDLAA IKREWAGGTR MDHFQLDHSR TSLQALVSVD ENFVYHEL
//
