ID V5BH74_TRYCR Unreviewed; 610 AA.
AC V5BH74;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Carnitine/choline acetyltransferase {ECO:0000313|EMBL:ESS67069.1};
GN ORFNames=TCDM_04302 {ECO:0000313|EMBL:ESS67069.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS67069.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS67069.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS67069.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS67069.1}.
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DR EMBL; AYLP01000036; ESS67069.1; -; Genomic_DNA.
DR AlphaFoldDB; V5BH74; -.
DR EnsemblProtists; ESS67069; ESS67069; TCDM_04302.
DR VEuPathDB; TriTrypDB:TCDM_04302; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF60; O-PALMITOYLTRANSFERASE II, PUTATIVE-RELATED; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ESS67069.1}.
FT DOMAIN 19..594
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 316
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 610 AA; 67053 MW; 3B159D0FF5D8352F CRC64;
MKRVLAKDLS VNVLKLPRLP IPSIQQTAER YRTSILPLKP ADTVKAHLVK LDTFLAGSAV
TLQNALLEAN KAAEAEGGYP YSYIEPIWDN MYLSNRAPLP VNTNPAILVK KVKNAGETQP
SVAASIVYGI AKWVQNVLKE GVEVRDANMD LSPMLRQFGA SLFPGEKADE FLITPFEKLR
HIIVLHDGHL YAVRVFDDQL VPLEQAVIQK CFEYILSITP DTDNTTPVSV LTAGNREVWA
GAYAELVRTP ENAETLKKVH EGIVVVCLDS KKWEEDDGLK NGAMLHGNKE ESENRWYDKH
QVIVSADGQV AFNFEHSGSD AVQWARWVGD VLQSIESKAV ATTTAAAVDT TQVTSLVEPL
RVTFGKTFAG HIRSARTEAL DLISNTALGQ LHLPFGKTQL KQLGVSPDAF VQMCFHVAFH
KCRNKLAPTY EAATTSCFFH GRTETIRSAT QEMLTLAEAV NKETKESATP KESERAALLA
LIKAASDRHT TLAKAASNGE GVDRHLTALN RLAVERNDNA ALNFFNDYTY NSCCKWVLST
SNVSYPWVER FIFGPVTPNG YGLGYVVGEN EVRIMLSAFT NSPSTNVEDM NAAIGVSATR
LYTVLAGSKL
//
