ID V5BXD4_9GAMM Unreviewed; 735 AA.
AC V5BXD4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Carbonic anhydrase 2 {ECO:0000313|EMBL:ESS69198.1};
DE EC=4.2.1.1 {ECO:0000313|EMBL:ESS69198.1};
GN Name=mtcA {ECO:0000313|EMBL:ESS69198.1};
GN ORFNames=MGMO_138c00360 {ECO:0000313|EMBL:ESS69198.1};
OS Methyloglobulus morosus KoM1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methyloglobulus.
OX NCBI_TaxID=1116472 {ECO:0000313|EMBL:ESS69198.1, ECO:0000313|Proteomes:UP000017842};
RN [1] {ECO:0000313|EMBL:ESS69198.1, ECO:0000313|Proteomes:UP000017842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KoM1 {ECO:0000313|EMBL:ESS69198.1,
RC ECO:0000313|Proteomes:UP000017842};
RX PubMed=24356841;
RA Poehlein A., Deutzmann J.S., Daniel R., Simeonova D.D.;
RT "Draft Genome Sequence of the Methanotrophic Gammaproteobacterium
RT Methyloglobulus morosus DSM 22980 Strain KoM1.";
RL Genome Announc. 1:e01078-13(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692}.
CC -!- SIMILARITY: Belongs to the beta-class carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00006217}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS69198.1}.
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DR EMBL; AYLO01000128; ESS69198.1; -; Genomic_DNA.
DR RefSeq; WP_023496096.1; NZ_AYLO01000128.1.
DR AlphaFoldDB; V5BXD4; -.
DR STRING; 1116472.MGMO_138c00360; -.
DR PATRIC; fig|1116472.3.peg.3465; -.
DR eggNOG; COG0288; Bacteria.
DR eggNOG; COG0659; Bacteria.
DR OrthoDB; 9769739at2; -.
DR Proteomes; UP000017842; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd03378; beta_CA_cladeC; 1.
DR Gene3D; 3.40.1050.10; Carbonic anhydrase; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR001765; Carbonic_anhydrase.
DR InterPro; IPR036874; Carbonic_anhydrase_sf.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF215; C4-DICARBOXYLIC ACID TRANSPORTER DAUA; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF00484; Pro_CA; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SMART; SM00947; Pro_CA; 1.
DR SUPFAM; SSF53056; beta-carbonic anhydrase, cab; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:ESS69198.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017842};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..395
FT /note="SLC26A/SulP transporter"
FT /evidence="ECO:0000259|Pfam:PF00916"
SQ SEQUENCE 735 AA; 79182 MW; 64A7B6F993ECE65D CRC64;
MSGTVNPNQP KNDFALFAHL KSDIPAGIAV FLVSIPLSLG IALTSGAPLF AGLITGIVGG
LVVAPISNSA LGISGTAAGL ALIVAPAIAK FGFNGYLLAV IFAGSVQILM GLLKAGVIAY
YFPSSIVNGM LMGIGLIILL KQIPHAIGDD LDYEGNFTYT QPDHYSSFTE LFRMLGEAQP
GALLIAIVSL GVILLWESPI IKKLPLFRLI PAPLMAVIAG ILLNTLLQNL YPRIALSEAH
LVTIPEVQNF SSLLLQLHFP DFNQLTNPDI YYFGLMLAVV ASLETLLTLD AVDKLDTYKR
ITASNRELIA QGIGNISCGL IGGLPLTQVV VRSSINALSG AKTHFAAVVN GLLLLLTVLM
MPTVLNKIPL ASLAAILIVV GVKLIKPDTI KTIYQSGWYR FIPFCATVLG LVFTNILFGI
LIGLVTALFS VLLENHKSAA YFKETHIGNK IIFRLSEHVS FLNRANVQTT LESLPAHSEV
VIDATRSKYI DYDVYEIIQN FKSDAHHKHI KLILENMRGY GSLPPIENAR AQTYKSQQLL
TPDKVLALLK EGNERFVYNL KSNRNLLEQV NDTRDGQFPI AIILSCMDSR TSVELIFDLG
LGDVFSARIA GNIINDDILG SMEYACKLAG SKLIVVLGHS HCGAINGACT DAHLDHLTGL
LAKIKPAIDC VQSEVGGNKT LDNEELVQKV ADKNVQLSVE NIRKQSAVLA GLEAAGDIAI
IGGMYDIETG KVEFL
//
