ID   V5D5E8_TRYCR            Unreviewed;       591 AA.
AC   V5D5E8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   ORFNames=TCDM_09618 {ECO:0000313|EMBL:ESS62691.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS62691.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS62691.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS62691.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS62691.1}.
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DR   EMBL; AYLP01000167; ESS62691.1; -; Genomic_DNA.
DR   EnsemblProtists; ESS62691; ESS62691; TCDM_09618.
DR   VEuPathDB; TriTrypDB:TCDM_09618; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT   DOMAIN          273..551
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          196..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   591 AA;  66256 MW;  FD68CAEEEDAAD2F2 CRC64;
     MEPLTWLPAE RYFYPLLNSI GAYQRYTYRL RAVCDAQRQK LLLSGDIEQN PGPIAVLQMN
     VYCLTPSKLA TLMAQGADII AIQETWKSSE QIASMHTGDY VLYAQLRIGK GGGVAVLVRT
     TLRSKRIPLT IPQHDXXXXR AANALNRIFL PYHPSHKAVR FSKGINRQSA CLNINASFLF
     GQQNNNESAA TFTSFSSLSS SSEPQDKNEA ATTSGLVAHL HSPLDAPFNR TELLAALRNT
     PYGKAPGPDE VCSEALRHIL SKGLRFLLRC INRSWTTGTI PAGWKRATIV PLLKPGKSPE
     LLESYRPISL TSIVSKVAEK MVLKRLPWVW TPHPHQYAYR SMRSTTMQLA HLIHEVEHNR
     NHYFQVSLPK KSGIGNQLHY RPHRALLVLV DFSKAFDSID HRVLSRLLAN IPGVNCRMWL
     RNFLCGRYAK TRVGHRNSDR RPMLRGVPQG SVLGPYLFSL YVHPLLNLLN SFAGVTADMY
     ADDLSIIVKG QSREDVIPTA NMVLQKLHAW SQENGLAINP SKCEAAWFTL STHTESDYDR
     EXXXAFIPQF IGDNREGQHK LRCTPMQLQD GIPCAASSPR EADDPPYPTQ A
//