ID V5F5P4_9VIBR Unreviewed; 819 AA.
AC V5F5P4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895,
GN ECO:0000313|EMBL:GAD90889.1};
GN ORFNames=VHA01S_059_00140 {ECO:0000313|EMBL:GAD90889.1};
OS Vibrio halioticoli NBRC 102217.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1219072 {ECO:0000313|EMBL:GAD90889.1, ECO:0000313|Proteomes:UP000017800};
RN [1] {ECO:0000313|EMBL:GAD90889.1, ECO:0000313|Proteomes:UP000017800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 102217 {ECO:0000313|EMBL:GAD90889.1,
RC ECO:0000313|Proteomes:UP000017800};
RA Ichikawa N., Kimura A., Ohji S., Hosoyama A., Fujita N.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAD90889.1, ECO:0000313|Proteomes:UP000017800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 102217 {ECO:0000313|EMBL:GAD90889.1,
RC ECO:0000313|Proteomes:UP000017800};
RA Isaki S., Kimura A., Ohji S., Hosoyama A., Fujita N., Hashimoto M.,
RA Hosoyama Y., Yamazoe A.;
RT "Whole genome shotgun sequence of Vibrio halioticoli NBRC 102217.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD90889.1}.
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DR EMBL; BAUJ01000059; GAD90889.1; -; Genomic_DNA.
DR RefSeq; WP_023405200.1; NZ_BAUJ01000059.1.
DR AlphaFoldDB; V5F5P4; -.
DR eggNOG; COG0557; Bacteria.
DR OrthoDB; 9764149at2; -.
DR Proteomes; UP000017800; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR013668; RNase_R_HTH_12.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08461; HTH_12; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00357; CSP; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 652..733
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 734..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..819
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 92903 MW; 93E4B176EF8C6D66 CRC64;
MSDSKSLDPH ADREAKNYEN PVPSREFLLS FLESAGVPMN RNDLFTALEL AGEDQYEGLR
RRLNAMLRDG QLVFTRRQCY ALPDKLEMIK GYVIGHKDGF GWVRPEGVIG KEQDLVLPFH
QMRSIIHGDY VLAQQSGTDK RGRKEARIVR VLEERAMKIV GRFFLEFGHA YVVADDSRIH
HDILIPKEHR MGARMGNVVV IEVTDRGNRS RGMSGKVVEV LGENLAPGME TQIAIRTHQI
PNEWPEEVTK QIASLAEEVP EEAKKGRVDL RELPLVTIDG EDARDFDDAV YCEKKKSGGW
RLWVAIADVS YYVRPDSALD KEAINRGNSV YFPSQVVPML PEVLSNGLCS LNPQVDRLCM
VCEMTVSESG KLSGYKHYEA VMNSHARLTY NKVNDILNGD QELNQRYETL VPHLQELHNM
YRTLKQSRDL RGAIEFETVE TKFIFNADRK IDRIEPVVRN DAHKLIEECM ILANIASASL
VEKLKEPALY RVHETPGEQR LVGFKDFLSE LGLTLNGGLA PSPTDYADLM HIVTQRPDKE
LIQTMLLRSM KQAVYNPDNA GHFGLALKRY AHFTSPIRRY PDLLLHRAIK YLIAKQEGRN
TDRWTPTGGY HYSFDDMDVF GEQCSMTERR ADDATRDVTD WLKCEYMQDH VGEELDGVIA
NVTGFGFFVR LTELHIDGLV HISTLANDYY RYDAISQRLV GESSGQIYRL GDTVKVKVLA
VNLNDKQIDF EMVGSQRTPR GKGKTAKKRL VEDAKRFDDK KKSGSSEGRR SRRAKAKVEP
TVRPDGSKDS APAPKKPKSN KAKKNKARGK KNTARAPKK
//
