ID V5FIN9_BYSSN Unreviewed; 1165 AA.
AC V5FIN9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|ARBA:ARBA00044146};
GN ORFNames=PVAR5_0150 {ECO:0000313|EMBL:GAD91578.1};
OS Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces
OS variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=1356009 {ECO:0000313|EMBL:GAD91578.1, ECO:0000313|Proteomes:UP000018001};
RN [1] {ECO:0000313|Proteomes:UP000018001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=No. 5 / NBRC 109023 {ECO:0000313|Proteomes:UP000018001};
RX PubMed=24407650; DOI=10.1128/genomeA.01162-13;
RA Oka T., Ekino K., Fukuda K., Nomura Y.;
RT "Draft genome sequence of the formaldehyde-resistant fungus Byssochlamys
RT spectabilis No. 5 (anamorph Paecilomyces variotii No. 5) (NBRC109023).";
RL Genome Announc. 2:E0116213-E0116213(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD91578.1}.
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DR EMBL; BAUL01000002; GAD91578.1; -; Genomic_DNA.
DR AlphaFoldDB; V5FIN9; -.
DR eggNOG; KOG2454; Eukaryota.
DR HOGENOM; CLU_274743_0_0_1; -.
DR InParanoid; V5FIN9; -.
DR OrthoDB; 5743at2759; -.
DR Proteomes; UP000018001; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07098; ALDH_F15-22; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000018001}.
FT DOMAIN 95..580
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 705..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 1165 AA; 128014 MW; 7E7983BCFD0E3107 CRC64;
MDCIASHIPP WVLAAAEDLG LEPQWLSVGL VASCTLVAAY LGYAYLLCRR EAPVKFNVPL
PPEVRPNWIA KKWDDVQGED KVLLEAQARG QWNEKKIMSY CPADGRVLGA SGPGIKPETA
EGIDRAVQAA KRAQVEWAKT TFAERRRVLK TLLKYVLEHQ DEIVTACCLD SGKTKVDASF
GEILVTTEKL KWTIDHGEKA LRTESRPTNF LMMYKKNTVR YEPLGVVSAC VSWNYPFHNF
IGSVISGIFA GNGVVVKPSE QTAWCTGYFL DIVRGALISC GHPPDLVQSV VCLPNVADVL
TSHPDISQLT FIGSRPVAHK VCESAAKALL PVTVELGGKD PSVILDDSTT IKQLPDIASI
LMRGVFQSAG QNCIGVERVI ALPGVYDKLL DIVTPRIKAL RLGSIFLDSK PDPKDPSYKP
ITPDVGAVIS LNGFDRLESL IEDAVKHGAR LICGGKRYNH PRHPHGHYFT PTLLADVTPS
MRIAQTELFA PVFVLMRASS VPDAIAIANS TEYALGASVF GFNSRDVEAC VSGIKSGMVA
VNDFGSYYAV QLPFGGVKGS GYGRFAGDEG LRGVSNVKAV CVDRFPRLMA TKIPPTVDYP
IYKGDGDRKN GSGAWEMCKG VVETGYQLTL AGRASGIMKI LKNLDDGVAD GSDAVDDGHQ
AAADGVEDRR NLLSGCWGAN DYPTISLASA VSTGMELTPI RVRGRRKRRA AANTKGLEEK
ENAESKSVSL RRLKGGRPMM SFADKAASQS QTVARRHVPE KTSSGRRRRK LSRLECLPVE
LIEKIFLYSL DVDLPRSSPA LAAALSRERM YRVFILLSFW NDVPVENDPA RPAIARILAP
AEYERLDDER RKALQSDVLR CRWCTIQRIL AELPELMNFA IQKYWIGAGI TMDEINQRRF
DHFLARNGGI RNFDGTGPNG NHYTLTVTPL LSIIVACVET QEINTYRILS VKGFPDGLLR
GDDGFSDDDI AYLETLRTGH GFDAPGTDVS FSRDALQQGI HNALIEHNSR ALSALLKIDE
YFTRHRLESE GTSSNTFYSI PPEHFHTAVT IAGDDPTLFQ LLLRTNAESL PADDSSITQW
AMDLNSAFGS WLLDFMVQLP EHIDAARSDP RTAALFYMGR ANPDIELGRR YLDEVLGVTE
LSSWLDETEF DVTSLWEAES SDSPS
//
