ID V5G6E0_BYSSN Unreviewed; 755 AA.
AC V5G6E0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=nicotinamide-nucleotide adenylyltransferase {ECO:0000256|ARBA:ARBA00012390};
DE EC=2.7.7.1 {ECO:0000256|ARBA:ARBA00012390};
GN ORFNames=PVAR5_8777 {ECO:0000313|EMBL:GAE00044.1};
OS Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces
OS variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=1356009 {ECO:0000313|EMBL:GAE00044.1, ECO:0000313|Proteomes:UP000018001};
RN [1] {ECO:0000313|Proteomes:UP000018001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=No. 5 / NBRC 109023 {ECO:0000313|Proteomes:UP000018001};
RX PubMed=24407650; DOI=10.1128/genomeA.01162-13;
RA Oka T., Ekino K., Fukuda K., Nomura Y.;
RT "Draft genome sequence of the formaldehyde-resistant fungus Byssochlamys
RT spectabilis No. 5 (anamorph Paecilomyces variotii No. 5) (NBRC109023).";
RL Genome Announc. 2:E0116213-E0116213(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate
CC + NAD(+); Xref=Rhea:RHEA:21360, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57540; EC=2.7.7.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001084};
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from
CC nicotinamide D-ribonucleotide: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004658}.
CC -!- SIMILARITY: Belongs to the eukaryotic NMN adenylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00007064}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE00044.1}.
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DR EMBL; BAUL01000350; GAE00044.1; -; Genomic_DNA.
DR AlphaFoldDB; V5G6E0; -.
DR eggNOG; KOG3199; Eukaryota.
DR HOGENOM; CLU_368800_0_0_1; -.
DR InParanoid; V5G6E0; -.
DR OrthoDB; 5488885at2759; -.
DR UniPathway; UPA00253; UER00332.
DR Proteomes; UP000018001; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004515; F:nicotinate-nucleotide adenylyltransferase activity; IEA:InterPro.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09286; NMNAT_Eukarya; 1.
DR CDD; cd05014; SIS_Kpsf; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR005248; NadD/NMNAT.
DR InterPro; IPR045094; NMNAT_euk.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035474; SIS_Kpsf.
DR NCBIfam; TIGR00482; nicotinate (nicotinamide) nucleotide adenylyltransferase; 1.
DR PANTHER; PTHR38418; SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860); 1.
DR PANTHER; PTHR38418:SF2; SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860); 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000018001}.
FT DOMAIN 403..553
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 81456 MW; 7C4EBC0ACFF580A1 CRC64;
MATSGEKSDD VHQLPPSLPP APMEDYAFPE QRLKKVMDDP EKTPLLLVAC GSFSPITYLH
LRMFEMASDY VKFSTDFELI GGYLSPVSDA YRKAGLASAE HRIAMCQLAV EQTSDWLMVD
PWEPMQKEYQ PTAIVLDHFD HEINTVRKGI DTGNGTRKPV RVALLAGADL IHTMSTPGVW
SEKDLDHILG KYGSFIVERS GTDIDEALAS LQPWKDNIYV IQQLIQNDVS STKIRLFLRR
EMSVRYLIPV PVIHYIEQHH LYEDDGAAGT KTNEKGKGKQ VGIRQGKYVF PLLNSPQGLA
CLLVIAAATA SMAFIAMAPS KQPITPVSPS ISSISSLPDA MPPLTMTPPE PEDPRLRTND
DAAAVVTAIH VIATEKAALA NLECIYQTDR LAQENMARAV NQIVRTIKDG GKLVVCGVGK
SGKIGKKLEA TMNSMGIYSA FLHPTEALHG DLGMIRPNDT LLLISFSGKT PELLLLLPHI
PSTVPVIAMT SHMHPATCPL LSFQYPEMGI LLPAPIHEDE ESSFGVCAPT SSTTVALALG
DALAIAAARK LHPLPGKGPA EVFKSFHPGG AIGAALSPPT PISIPTSAPS ISPTSMPSDY
LQAKPLGSYP VTGATNPDNK HGTRVSDIAV PLENIPTVSS LSDIRILDIL LTAIQNPTSK
SWVKLSSTEI IPPSRVRSLS VGSSVDMNVS DVSEPLAVER KDWLFVPAVS ALEDVRQLVS
DTSRAGSNVS VVGLLNTENE LVAVVEPEQV FDKSN
//
