ID V5GIC5_IXORI Unreviewed; 300 AA.
AC V5GIC5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Putative megalin {ECO:0000313|EMBL:JAB69960.1};
DE Flags: Fragment;
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB69960.1};
RN [1] {ECO:0000313|EMBL:JAB69960.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB69960.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; GANP01014508; JAB69960.1; -; mRNA.
DR AlphaFoldDB; V5GIC5; -.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..300
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004733883"
FT DISULFID 33..45
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 40..58
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 73..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 80..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 92..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 134..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 154..166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 161..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 173..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 300
FT /evidence="ECO:0000313|EMBL:JAB69960.1"
SQ SEQUENCE 300 AA; 33464 MW; 35261E64D43783D5 CRC64;
MGFSDKRLLE TLCLLLCVAL ASDSAEVEET TTCSTDNFRC SNGRCVPQRW VCDYQRDCEG
GEDEHQSCEY RVCEEGDHKC GSGLCVPASK KCDGYYDCRD ESDEASCATN GTSCRLNEFR
CRHGNKCIDE SKKCDHWDDC GDNSDEEGCD FAPCNEGQFR CTNAICIPIR WRCDGHSDCS
DQSDERNCTS VTCLDTKFLC PSEKKCIDKS KLCDGKQDCD DGADEKKNCS SNLCRTLSCE
YGCRASLDGG DCFCAPGMTI NTKDKRTCVG KQTPRERAVL RGSMDFREDI LHTSCVSFFF
//
