ID V5GVI7_ANOGL Unreviewed; 597 AA.
AC V5GVI7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=SARM1 {ECO:0000313|EMBL:JAB65697.1};
OS Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Chrysomeloidea; Cerambycidae; Lamiinae; Lamiini; Anoplophora.
OX NCBI_TaxID=217634 {ECO:0000313|EMBL:JAB65697.1};
RN [1] {ECO:0000313|EMBL:JAB65697.1}
RP NUCLEOTIDE SEQUENCE.
RA Scully E.D., Hoover K., Carlson J.E., Tien M., Geib S.M.;
RT "Midgut Transcriptome Profiling of Anoplphora glabripennis, a
RT Lignocellulose Degrading, Wood-Boring Cerambycid.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the SARM1 family.
CC {ECO:0000256|ARBA:ARBA00008291}.
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DR EMBL; GALX01002769; JAB65697.1; -; Transcribed_RNA.
DR AlphaFoldDB; V5GVI7; -.
DR EnsemblMetazoa; XM_018721916.2; XP_018577432.1; LOC108915787.
DR GO; GO:0003953; F:NAD+ nucleosidase activity; IEA:InterPro.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09501; SAM_SARM1-like_repeat1; 1.
DR CDD; cd09502; SAM_SARM1-like_repeat2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR039184; SARM1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR PANTHER; PTHR22998; SARM1; 1.
DR Pfam; PF07647; SAM_2; 2.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunity {ECO:0000256|ARBA:ARBA00022588};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 242..306
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 312..379
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 391..534
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 549..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 66744 MW; 04CDC9992DFD0F64 CRC64;
MLHAFVQKKS NSVDHSRVGT GILEHLFKHS EETCSDVVRL GGLDALLFEC RKSDVETLRH
CAGALANLSL YGGAENQEAM IKRKVPMWLF PLAFHNDDNI KYYACLAITV LVANAEIEAE
VLQSGTLGLV EPFVTTHNPS EFAKSNLAHA HGQSKTWLKN LVPVLSSKRE EARNLAAFHF
CMEAGIKKQQ GNTNIFSEIG AVESLKKVAS CPNAVASKYA AQALRLIGEE VPHKLSQQVP
LWSAEDVEEW VKQIGFAEIA SSFVESRVDG DLLLQLTEEN LRDDIGLTNG IKRKRFTREL
QKLKKMADYT SRDTANINNF LQTLGPEFSI YTYSLLNAGV ETKDSLRNIS EDQLLNECGI
MNSIHRYRIM EGIRQLENGL ANGLNEDNMD KSLDVFVSYR RSNGSQLASL LKVHLQLRGF
SVFIDVERLE AGKFDNNLLQ SIQKAKHFLL VLTPNALERC IGDHERKDWV HREIVAALSA
NCNIIPIIDN FTFPEADELP EDMRQVCHFN AVRWIHDYQD ACVDKLERFM RGELNSRCAD
GLMNRVGLSK GDITPGTPSN PSLVRQPPSY QRMHSNDSGS GKGSDKDTNG NSGLTRD
//
