ID   V5HF15_IXORI            Unreviewed;       803 AA.
AC   V5HF15;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Putative kalirin rhogef kinase {ECO:0000313|EMBL:JAB82220.1};
DE   Flags: Fragment;
OS   Ixodes ricinus (Common tick) (Acarus ricinus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB82220.1};
RN   [1] {ECO:0000313|EMBL:JAB82220.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB82220.1};
RX   PubMed=25765539;
RA   Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT   "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT   and midguts when blood feeding on the vertebrate host.";
RL   Sci. Rep. 5:9103-9103(2015).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; GANP01002248; JAB82220.1; -; mRNA.
DR   AlphaFoldDB; V5HF15; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00176; SPEC; 2.
DR   Gene3D; 1.20.58.60; -; 2.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR22826:SF201; LD43457P; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00435; Spectrin; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00150; SPEC; 2.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 2.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Kinase {ECO:0000313|EMBL:JAB82220.1};
KW   Transferase {ECO:0000313|EMBL:JAB82220.1}.
FT   DOMAIN          394..570
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          582..698
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          724..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..739
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:JAB82220.1"
FT   NON_TER         803
FT                   /evidence="ECO:0000313|EMBL:JAB82220.1"
SQ   SEQUENCE   803 AA;  92315 MW;  8CA7633A945D37F8 CRC64;
     AEVKRVRLEQ CIQLCQLEKD ANQVNTWIRN GEAMLSATFV IPTCLPEAEQ LRSQHEQFQL
     AIEKTHASAI QIQQRAESLV QANHYDPAAV RSVAETVDTW WHRMMTHAED RHRMVTASLR
     FYKTAEQVYS VLDSLEREYR RDEDWCAGGE ESEGTNRGAQ LAQLLAKHQE KKEAFLKACT
     MARRNAETFL KYTARCSQHC AGHGDSNYRG PEAKVKALME QLLKQENKVL EYWTVRKKRL
     DQCQQYVLFE RSAKQALGWI KDTGEHYLTS HNSVGDSREE TERLLKEHNE FKGNAKETRE
     KVRLLLQLAD SLVERGHAHA SAIKCWVAAV DQGYKDFSLR MDQYRSQLER KLGIQVEETK
     ELSLDRNSDP NLESKVKEST VKELNEEKRK SARRKEFIMA ELLQTERSYV KDLETCIHTY
     MAELRNPDIS RPPGIVGKEL VLFGNMEEIY EFHNSVFLKE LEKYETMPED VGHCFVTWAQ
     KFEIYVKYCK NKPESNALLI QHSRSFFEEI QHKHGVPHPI PAYLIKPVQR ITKYQLLLKD
     LLACCEDGVQ GEIRDGLEVM LNVPKKANDA MHLSLLDGCD VSLDQLGEVV LQDSFQVFDS
     RAIIRKGRER HIFLFELYLL FSKEMKDPNG KVKYVYKQKL MTSEVGITEH VEGDECKFAV
     WTAVWTEHGP TSENKIILKA SSLETKQTWV KKLRQVIQET YFNSALSTLN LNKSSKLTSK
     LFSNRSSRDL EDSSQDEGLT DLQERVSVAS FGSSNTTDSE KGTDPDDQTP SSQGEPFGES
     RRGARELCAI SWRPAELVPP VVD
//