ID V5HM36_IXORI Unreviewed; 313 AA.
AC V5HM36;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=BPTI/Kunitz inhibitor domain-containing protein {ECO:0000259|PROSITE:PS50279};
OS Ixodes ricinus (Common tick) (Acarus ricinus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB76472.1};
RN [1] {ECO:0000313|EMBL:JAB76472.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB76472.1};
RX PubMed=25765539;
RA Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT and midguts when blood feeding on the vertebrate host.";
RL Sci. Rep. 5:9103-9103(2015).
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DR EMBL; GANP01007996; JAB76472.1; -; mRNA.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0044562; P:envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism; IEA:UniProt.
DR CDD; cd22625; Kunitz_ixolaris_1; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 3.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR PANTHER; PTHR10083:SF385; BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10083; KUNITZ-TYPE PROTEASE INHIBITOR-RELATED; 1.
DR Pfam; PF00014; Kunitz_BPTI; 3.
DR SMART; SM00131; KU; 4.
DR SUPFAM; SSF57362; BPTI-like; 3.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 3.
PE 2: Evidence at transcript level;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..313
FT /note="BPTI/Kunitz inhibitor domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004738067"
FT DOMAIN 28..80
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 205..254
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 260..313
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 313 AA; 35178 MW; 5F82D49FA4C72A0C CRC64;
MHKEILWTLI TTALGLCSGQ NPKDGNVCLE TPELGHGRNI VKGWSYNPYL DKCYVFDHVX
XXYYNNENIF LNESACNQRC RPQFPAKCYA QPPLSKGTLD LPVVTYDPTT GRCLAIRAPD
EDKTKNSSLV SDASFAPKGR CRDTDLRLCL NPTEADCEHL ENPSTSYRYD NVSQTCKKSV
DGTCGGFQSA EKCFQRCGIL VDNKCTLPIQ NITTCESPTK RYGYNKEKGQ CEELLGCTDG
GNSFEEAKEC WSLCARTHRC DMSPDTGRFT NFGLVRRYYF DITKNECKPA RKLTKAVPGN
TNLFETAEEC KQI
//
