ID   V5I144_IXORI            Unreviewed;       379 AA.
AC   V5I144;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Putative glyoxylate/hydroxypyruvate reduct {ECO:0000313|EMBL:JAB82907.1};
DE   Flags: Fragment;
OS   Ixodes ricinus (Common tick) (Acarus ricinus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=34613 {ECO:0000313|EMBL:JAB82907.1};
RN   [1] {ECO:0000313|EMBL:JAB82907.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Salivary gland and midgut {ECO:0000313|EMBL:JAB82907.1};
RX   PubMed=25765539;
RA   Kotsyfakis M., Schwarz A., Erhart J., Ribeiro J.M.;
RT   "Tissue- and time-dependent transcription in Ixodes ricinus salivary glands
RT   and midguts when blood feeding on the vertebrate host.";
RL   Sci. Rep. 5:9103-9103(2015).
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DR   EMBL; GANP01001561; JAB82907.1; -; mRNA.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   2: Evidence at transcript level;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:JAB82907.1}.
FT   DOMAIN          158..312
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
FT   REGION          90..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:JAB82907.1"
SQ   SEQUENCE   379 AA;  41916 MW;  B15CC46D732C4F39 CRC64;
     TLLLTKPASE MSRRKIYVLS RIPNLGHQLT DALKDNASVV EITAKFTIHD DEPTIKPEVV
     QRLQSAEILI TDTHIXXDIL YKTTEHEVGP TDIGRCGQPP SSSRIDRKPP PTYTIARASC
     FGILMAEYVS CLESYNIREG SLHATTILQE KERVGLIRTS LQFRTLSDLT VGILGAGVIG
     QEIASTLKQF GTAVHGLARR RRSLEELTRS SFEMIHSELS ELLKNSDYIV NALPSTPNTT
     GMLNGEVLKN CRKKPVLINI GRGTIISEES IIEALNNGWI SGAILDVFAT EPLPVDSPLW
     SQPNVIITPH MSGPSRPHES IGPGDAPEWH CCRHQKCFHG SSLMCFFLCI LGECFQFSLV
     KYLVLVETYG KSNEGIVFV
//