ID V5IL35_NEUCR Unreviewed; 814 AA.
AC V5IL35;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=NADP-dependent malic enzyme {ECO:0000313|EMBL:ESA42428.1, ECO:0000313|EMBL:ESA42429.1};
GN ORFNames=NCU03651 {ECO:0000313|EMBL:ESA42428.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA42428.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:ESA42428.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805}, and OR74A
RC {ECO:0000313|EMBL:ESA42428.1};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [2] {ECO:0000313|EMBL:ESA42428.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OR74A {ECO:0000313|EMBL:ESA42428.1};
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Henn M.R., Hood H., Radford A., Collins R.A., Walker B.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Allen A.W., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B., Chen Z.,
RA Gainer-Dewar J., Gnerre S., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J.B., McCowan C., Murphy C.,
RA Pearson M.D., Poon T.W., Priest M., Roberts A., Saif S., Shea T.D.,
RA Sisk P., Shea T., Sykes S., Zucker J., Kodira C., Bowman B., Colot H.,
RA Ebbole D., Rasmussen C., Baker C., Kalkman E., Chen C.-H., Shi M.,
RA Mathur R., Lambreghts R., Collopy P., Mehra A., Schweredtfeger C., Hong C.,
RA Belden W., Glass N.L., Borkovich K., Dunlap J., Lander E., Wortman J.,
RA Nusbaum C., Sachs M., Birren B.;
RT "The Genome Sequence of Neurospora crassa strain OR74A.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM002240; ESA42428.1; -; Genomic_DNA.
DR EMBL; CM002240; ESA42429.1; -; Genomic_DNA.
DR RefSeq; XP_011394557.1; XM_011396255.1.
DR RefSeq; XP_011394558.1; XM_011396256.1.
DR AlphaFoldDB; V5IL35; -.
DR STRING; 367110.V5IL35; -.
DR PaxDb; 5141-EFNCRP00000003417; -.
DR EnsemblFungi; ESA42428; ESA42428; NCU03651.
DR EnsemblFungi; ESA42429; ESA42429; NCU03651.
DR GeneID; 3876882; -.
DR KEGG; ncr:NCU03651; -.
DR VEuPathDB; FungiDB:NCU03651; -.
DR InParanoid; V5IL35; -.
DR OrthoDB; 1069499at2759; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IBA:GO_Central.
DR GO; GO:0006090; P:pyruvate metabolic process; IBA:GO_Central.
DR CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR PANTHER; PTHR23406:SF32; NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 327..507
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 517..778
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT REGION 67..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 89932 MW; A3AA1F743ACAC56B CRC64;
MGKNRLPVSP WTVLMSGATA PRLQNVLSRP VLSSKRDAGR TSSHHLLKSL LLASRFAAST
LVATTSSAGA SRSTGTSSPD PGPTINKSQT NRNPSTYTSP PNSLSRTFSA SNLLAWYRTL
PSPYFNLSGH LDDLSSLIRP FLAFLDPSSL SSPYSMASTS YAFSTSSGSD FSTPRSSSPH
SSASVASARS SHSSTFSAGK RLSMSSVRRT SASNPMSSVD LSTIEEALKM ANLDTLKGYC
QKTYGEVHQE TTTEYISQEE ARGYQVLNQP HWNKGTSFTP EERVAKNLTG LIPHVMEDSE
KQVERALKMI RTRQTDIDRY LYLSTIKSQN VDLFYRLLMD HAKEMMPLVY TPTIGDVCLQ
YSTLYTRPEA LYISIKQRKS IRTILRNWPY PQPEICVVTD GSRILGLGDL GVNGVGIPIG
KLALYTAAAG IHPDKTLPIV LDCGTANETN LKDPLYLGLR QKRIPVAEQQ EFMDEFMEAA
AEVFPDMVVQ FEDFESEKAF NYLDRYRDQY KCFNDDIQGT GAVVLAGYIG AVNLSNVPIE
EQRLVFMGAG SAGVGVAKQL VEYYTKRGLS EQQAKDKFWL VDTKGLVTKD RGDKLAEHKK
YFARTDNNGH QFRTLEEVIE YVKPSALVGL TATHGVFTES VVRALKASVD AGGLGRRPIL
FPLSNPLTKA ECTFKEAIDW TDGTVLFASG SPFSSYTTNG VTYHPNQGNN VYVFPGIGLG
AILAKATRVT DDMIYTSAAA LANSLNADEV KQGLIYPRID RVREASVIVA REVMKSARRE
GVSTLPEEQW LEWEEWGDVD LERYIKQHIY DPKF
//
