ID V5KBU7_ECOLX Unreviewed; 423 AA.
AC V5KBU7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Error-prone lesion bypass DNA polymerase V ImpB/UmuC {ECO:0000313|EMBL:AGW45063.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:AGW45063.1};
DE SubName: Full=Protein ImpB {ECO:0000313|EMBL:OTE56253.1};
DE SubName: Full=Translesion error-prone DNA polymerase V subunit UmuC {ECO:0000313|EMBL:PDV42267.1};
GN Name=impB {ECO:0000313|EMBL:AGW45063.1};
GN ORFNames=AW118_24355 {ECO:0000313|EMBL:OTE56253.1}, BER14_25970
GN {ECO:0000313|EMBL:PDV42267.1};
OS Escherichia coli.
OG Plasmid pO111-CRL-115 {ECO:0000313|EMBL:AGW45063.1}, and
OG Plasmid pO26-CRL-125 {ECO:0000313|EMBL:AGW45196.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AGW45063.1};
RN [1] {ECO:0000313|EMBL:AGW45063.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pO111-CRL-115 {ECO:0000313|EMBL:AGW45063.1}, and pO26-CRL-125
RC {ECO:0000313|EMBL:AGW45196.1};
RX PubMed=24223859;
RA Venturini C., Hassan K.A., Roy Chowdhury P., Paulsen I.T., Walker M.J.,
RA Djordjevic S.P.;
RT "Sequences of Two Related Multiple Antibiotic Resistance Virulence Plasmids
RT Sharing a Unique IS26-Related Molecular Signature Isolated from Different
RT Escherichia coli Pathotypes from Different Hosts.";
RL PLoS ONE 8:E78862-E78862(2013).
RN [2] {ECO:0000313|EMBL:AGW45063.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pO111-CRL-115 {ECO:0000313|EMBL:AGW45063.1}, and pO26-CRL-125
RC {ECO:0000313|EMBL:AGW45196.1};
RA Venturini C., Bhattacharya P., Hassan K.A., Paulsen I.T., Walker M.J.,
RA Djordjevic S.P.;
RT "Derivate Tn3 family transposons play a central role in the evolution of
RT multiple antibiotic resistance on virulence plasmids in enterohemorrhagic
RT Escherichia coli.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PDV42267.1, ECO:0000313|Proteomes:UP000220499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OLC1334 {ECO:0000313|EMBL:PDV42267.1,
RC ECO:0000313|Proteomes:UP000220499};
RX PubMed=28221970; DOI=.4315/0362-028X.JFP-16-220;
RA Knowles M., Stinson S., Lambert D., Carrillo C., Koziol A., Gauthier M.,
RA Blais B.;
RT "Genomic Tools for Customized Recovery and Detection of Foodborne Shiga
RT Toxigenic Escherichia coli.";
RL J. Food Prot. 79:2066-2077(2016).
RN [4] {ECO:0000313|EMBL:OTE56253.1, ECO:0000313|Proteomes:UP000194376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OLC1269 {ECO:0000313|EMBL:OTE56253.1,
RC ECO:0000313|Proteomes:UP000194376};
RA Carrillo C.D., Koziol A.G., Mathews A., Goji N., Lambert D.,
RA Huszczynski G., Deschenes M., Gauthier M., Amoako K., Blais B.;
RT "Application of genomics in the determination of verotoxigenic Escherichia
RT coli toxin subtypes.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:PDV42267.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OLC1334 {ECO:0000313|EMBL:PDV42267.1};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; KC340959; AGW45063.1; -; Genomic_DNA.
DR EMBL; KC340960; AGW45196.1; -; Genomic_DNA.
DR EMBL; NEOL01000055; OTE56253.1; -; Genomic_DNA.
DR EMBL; NWRY01000057; PDV42267.1; -; Genomic_DNA.
DR RefSeq; WP_000457473.1; NZ_VTOT01000097.1.
DR RefSeq; YP_008864053.1; NC_022992.1.
DR RefSeq; YP_008864719.1; NC_022996.1.
DR PATRIC; fig|562.6983.peg.1687; -.
DR Proteomes; UP000194376; Unassembled WGS sequence.
DR Proteomes; UP000220499; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd01700; PolY_Pol_V_umuC; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025188; DUF4113.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11076:SF34; PROTEIN UMUC; 1.
DR Pfam; PF13438; DUF4113; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00023199};
KW Nucleotidyltransferase {ECO:0000313|EMBL:AGW45063.1};
KW Plasmid {ECO:0000313|EMBL:AGW45063.1};
KW SOS mutagenesis {ECO:0000256|ARBA:ARBA00023199};
KW SOS response {ECO:0000256|ARBA:ARBA00023236};
KW Transferase {ECO:0000313|EMBL:AGW45063.1}.
FT DOMAIN 2..189
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 423 AA; 47576 MW; 972EBDF81FD07304 CRC64;
MFALADINSF YASCEKVFRP DLRNEPVIVL SNNDGCVIAR SPEAKALGIR MGQPRFQVRQ
MRLEKKIHVF SSNYALYHSM SQRVMAVLES LSPAVEPYSI DEMFIDLRGI NHCISPEFFG
HQLREQVKSW TGLTMGVGIA PTKTLAKSAQ WATKQWPQFS GVVALTAENR NRILKLLGLQ
PVGEVWGVGR RLTEKLNALG INTALQLAQA NTAFIRKNFS VILERTVREL NGESCISLEE
APPAKQQIVC SRSFGERITD KDAMHQAVVQ YAERAAEKLR GERQYCRQVT TFVRTSPFAV
KEPCYSNAAV EKLSLPTQDS RDIIAAACRA LNHVWREGYR YMKAGVMLAD FTPSGIAQPG
LFDEIQPRKN SEKLMKTLDE LNQSGKGKVW FAGRGTAPEW QMKREMLSPA YTTRWTDLPV
AQL
//
