ID   V5XHJ3_MYCNE            Unreviewed;       740 AA.
AC   V5XHJ3;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Threonine dehydrogenase {ECO:0000313|EMBL:AHC27492.1};
GN   ORFNames=D174_24400 {ECO:0000313|EMBL:AHC27492.1};
OS   Mycolicibacterium neoaurum VKM Ac-1815D.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=700508 {ECO:0000313|EMBL:AHC27492.1, ECO:0000313|Proteomes:UP000018763};
RN   [1] {ECO:0000313|EMBL:AHC27492.1, ECO:0000313|Proteomes:UP000018763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-1815D {ECO:0000313|EMBL:AHC27492.1,
RC   ECO:0000313|Proteomes:UP000018763};
RX   PubMed=24435872;
RA   Shtratnikova V.Y., Bragin E.Y., Dovbnya D.V., Pekov Y.A., Schelkunov M.I.,
RA   Strizhov N., Ivashina T.V., Ashapkin V.V., Donova M.V.;
RT   "Complete Genome Sequence of Sterol-Transforming Mycobacterium neoaurum
RT   Strain VKM Ac-1815D.";
RL   Genome Announc. 2:e01177-13(2014).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; CP006936; AHC27492.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5XHJ3; -.
DR   SMR; V5XHJ3; -.
DR   Proteomes; UP000018763; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd08255; 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43350:SF22; D-GULOSIDE 3-DEHYDROGENASE; 1.
DR   PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018763}.
FT   DOMAIN          49..371
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   740 AA;  78068 MW;  9B98B14615C9B9F7 CRC64;
     MKQAVQNLKT GEVSVREVPP PRLNRGGALV ATLSSLISAG TERNKIELGE KSMLGKAKAR
     PELARQVVEK ARQDGLKETY RTVMQRLEAP NLLGYSAAGR VLAVAPDVPG IEVGDLVACS
     GAGYANHAEV NFIPKHLLAK VPDGVSADEA AYGTLGCIAM HGVRQAEIGL GDRVLVVGLG
     LVGLIAAQLA RATGARVFGT DLDPRACALA ESIGVERAAP RASIEAVIGD ITGGVGVDAV
     VICAAAASND PIELAARLVR NRGRVVLVGT VGLTLPRDPF YMKEIELRYS RSYGPGRYDP
     GYEEHGHDYP IGYVRWTEQR NLAEFLRLVR DGRVDVATLT THRLPVDDAA DAYALISGRS
     PDETRPIGVL LQYPDGQAAA ARTQIAVKPR NRLPAERVGL GMVGAGNFAT RVLLPALMDT
     GKVQPVGITT SGGTTSGQVA QSYGFGHSTA DADALVNDSG VDAVVIATRH DSHAGLATQA
     LRAGKATFCE KPLATTWDDL EQVASAWTQS GAPLLVGFNR RFSPLTTKLK EALPRGVPRV
     MIARCNAGQM PPDHWMRDSI FGGGRIVGEL CHFLDLACAM AEGRPLRVSA EAIGSADSAE
     LADTIVVQVA FSCGSIASLQ YLGNGDPSIS KERIEVYCGG VVGIIDDFFA LEIAQGGKRK
     RSRGRRQEKG HREEMRLFVD LATGSGDLET VAEDAFWSSA LTLQVPWALA QGRAVLVDLP
     KALGGRGADA GLAGAGEQPG
//