ID   V5YWB7_SERMA            Unreviewed;       604 AA.
AC   V5YWB7;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   13-SEP-2023, entry version 28.
DE   RecName: Full=Phosphogluconate dehydratase {ECO:0000256|HAMAP-Rule:MF_02094};
DE            EC=4.2.1.12 {ECO:0000256|HAMAP-Rule:MF_02094};
GN   Name=edd {ECO:0000256|HAMAP-Rule:MF_02094,
GN   ECO:0000313|EMBL:BAO21196.1};
OS   Serratia marcescens.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615 {ECO:0000313|EMBL:BAO21196.1};
RN   [1] {ECO:0000313|EMBL:BAO21196.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IOMTU 115 {ECO:0000313|EMBL:BAO21196.1};
RA   Tada T., Miyoshi-Akiyama T., Kirikae T.;
RT   "Genetic environments surrounding aac(6')-Ial.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-
CC       dehydro-3-deoxy-6-phospho-D-gluconate. {ECO:0000256|HAMAP-
CC       Rule:MF_02094}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-
CC         gluconate + H2O; Xref=Rhea:RHEA:17277, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:57569, ChEBI:CHEBI:58759; EC=4.2.1.12;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_02094};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_02094};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|HAMAP-Rule:MF_02094};
CC   -!- PATHWAY: Carbohydrate metabolism; Entner-Doudoroff pathway.
CC       {ECO:0000256|HAMAP-Rule:MF_02094}.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC       {ECO:0000256|ARBA:ARBA00006486, ECO:0000256|HAMAP-Rule:MF_02094}.
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DR   EMBL; AB894481; BAO21196.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5YWB7; -.
DR   UniPathway; UPA00226; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004456; F:phosphogluconate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046177; P:D-gluconate catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009255; P:Entner-Doudoroff pathway through 6-phosphogluconate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR   HAMAP; MF_02094; Edd; 1.
DR   InterPro; IPR004786; 6-phosphgluc_deHydtase.
DR   InterPro; IPR042096; Dihydro-acid_dehy_C.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   InterPro; IPR037237; IlvD/EDD_N.
DR   NCBIfam; TIGR01196; edd; 1.
DR   PANTHER; PTHR43661; D-XYLONATE DEHYDRATASE; 1.
DR   PANTHER; PTHR43661:SF1; PHOSPHOGLUCONATE DEHYDRATASE; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|HAMAP-Rule:MF_02094};
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW   Rule:MF_02094};
KW   Gluconate utilization {ECO:0000256|ARBA:ARBA00023064, ECO:0000256|HAMAP-
KW   Rule:MF_02094}; Iron {ECO:0000256|HAMAP-Rule:MF_02094};
KW   Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_02094};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_02094};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_02094}.
FT   BINDING         155
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02094"
FT   BINDING         222
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02094"
SQ   SEQUENCE   604 AA;  64282 MW;  B4300765F6FEC3F1 CRC64;
     MINPTLSRVT QRIIDRSQAS RAAYLARIEA ARAQTVHRAQ LACGNLAHGF AACQPDDKAS
     LKNMVRSDIA IITAYNDMLS AHQPYEHYPQ RLKQALKAVG AVGQVAGGVP AMCDGVTQGQ
     DGMELSLMSR DVIAMSAAVG LSHNMFDGAL FLGICDKIVP GLVMAALSFG HLPALFVPAG
     PMSSGLPNKE KVRVRQLYAE GKADRLALLE AEAASYHGIG TCTFYGTANT NQMVMEVMGL
     HLPGASFVHP DTPLRDALND AAARQVTRLT DTAGNYLPIG RLVDEKVVVN GIVSLLATGG
     STNLTMHLVA MARAAGIIIT WDDFSELSEA VPLLCRIYPN GPADINQFQA AGGVPLVVRE
     LLQHGLLHED VHTVAGFGLR RYTQEPWLDN DQLVWREGVA GSLDASVIAS VTQPFEHHGG
     TKVMAGNLGR AVMKTSAVPA DNQIIEAPAV VFDSQHDIVP AFEAGKLDRD CVVVVRFQGP
     QANGMPELHK LMPPLGVLMD RGFKVALVTD GRLSGASGKV PSAIHVTPEA YTGGLLAKVR
     DGDPIRVNGR SGELQVLVDA DELARRTPCQ PDLSAEHIGC GRELFGALRS QLSGAEQGAC
     CIKF
//