ID V6CLR6_CAEEL Unreviewed; 982 AA.
AC V6CLR6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=UNC-44 {ECO:0000313|EMBL:CDK13513.1};
GN Name=unc-44 {ECO:0000313|EMBL:CDK13513.1,
GN ECO:0000313|WormBase:B0350.2j};
GN ORFNames=B0350.2 {ECO:0000313|WormBase:B0350.2j}, CELE_B0350.2
GN {ECO:0000313|EMBL:CDK13513.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CDK13513.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CDK13513.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CDK13513.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; BX284604; CDK13513.1; -; Genomic_DNA.
DR RefSeq; NP_001293786.1; NM_001306857.1.
DR AlphaFoldDB; V6CLR6; -.
DR SMR; V6CLR6; -.
DR PeptideAtlas; V6CLR6; -.
DR EnsemblMetazoa; B0350.2j.1; B0350.2j.1; WBGene00006780.
DR AGR; WB:WBGene00006780; -.
DR WormBase; B0350.2j; CE49406; WBGene00006780; unc-44.
DR OrthoDB; 5474900at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006780; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; V6CLR6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:V6CLR6,
KW ECO:0007829|PeptideAtlas:V6CLR6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 175..332
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 334..465
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 670..751
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 982 AA; 109491 MW; 1E364399B1944A93 CRC64;
MNETMFSESE DEGQAAEHEA VAAHEKDFSD NLTQGLQDST GVHMIHTGEQ LLQRSQELEN
GGAIPKINSG GMSPEKEFAK IAPVATSSPI ATSNSQSFGI APRAGSISGQ FQQQPLHGAG
PEDNLEELVR RAQNHPINAG NYDNGGVAML ENGHADNVPI GHHVTQPSKL QHRTFLISFL
VDARGGAMRG CRHSGVRIIV PPRKASQPIR VTCRYLRKDK LAHPPPLSEG EELASRILEM
APAGAKFLGP VILEVPHFAS LRDREREIVI LRSDDGQHWK EHQLEATEDA VQEVLNESFD
AEDLAQLDDL QTPRITRILT SDFPMYFAVV TRVRQEVHCV GPEGGVIISS VVPRVQAIFP
DGSLTKTIKV SVQAQPVPQE MVTRLHGNRV AVSPIVTVEP RRRKFHKPIT LCIPLPQSNN
RGMLTQYSGQ QGQEPPTLRL LCSITGGSAP AQWEDITGTT QLTFTGDEVS FTTTVSARFW
LMDCQTPRDA ARMAQEVYNE AISIPYMAKF AVFARRTFPV EGQLRVFCMT DDKEDKTLEK
QEHFKLIAKS RDVEVLKGKH QFLEFSGNLV PITKSGDQLS LFFLPFQENR LAFMVKTRSN
DDNEAATEGR IGFMAEPKIR SDALPPQQPI CTLAISLPEY TGEIKTAPPP KKDLTPFEQR
YGSALEKDLP EFVHQNVLKG IGADWPRLGR ALEVPHRDIQ HIRQNYPGQE CKNTLKIWIH
LKKEDANQDN LDQALRQIGR DDIVRSIAYG EPDALINYSQ ADSPSQKREP IRHFEEVPAA
TLVKREVRTE DLVTREPVQP THHVEQATTV VQEPSYSAPV HHSPVPEEPE MEEEAPVAEM
RTVVRTERHV HDSEDGPVVE ERTITTTYED DVAVNENIVD RTVPLNEDEQ QKWEELNRLA
DESSPSPAQR STIVAESTSE QVPEDVEQSV ESESHREDDG TIVTTTVTTS HISESPSGSP
TRRSVEPEEH RHSQHEDHEG ST
//
