ID V6DMX5_9LACO Unreviewed; 644 AA.
AC V6DMX5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Ribosome protection-type tetracycline resistance related proteins, group 2 {ECO:0000313|EMBL:CDK35368.1};
GN ORFNames=LSCP400_11761 {ECO:0000313|EMBL:CDK35368.1};
OS Ligilactobacillus salivarius cp400.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1273133 {ECO:0000313|EMBL:CDK35368.1, ECO:0000313|Proteomes:UP000018601};
RN [1] {ECO:0000313|EMBL:CDK35368.1, ECO:0000313|Proteomes:UP000018601}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cp400 {ECO:0000313|Proteomes:UP000018601};
RX PubMed=24526652; DOI=10.1128/genomeA.01231-13;
RA Mackenzie D.A., McLay K., Roos S., Walter J., Swarbreck D., Drou N.,
RA Crossman L.C., Juge N.;
RT "Draft Genome Sequence of a Novel Lactobacillus salivarius Strain Isolated
RT from Piglet.";
RL Genome Announc. 2:e01231-e01213(2014).
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDK35368.1}.
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DR EMBL; CBVR010000016; CDK35368.1; -; Genomic_DNA.
DR AlphaFoldDB; V6DMX5; -.
DR Proteomes; UP000018601; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 6..229
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 644 AA; 72637 MW; 719A1C95F4F8FD3C CRC64;
MPINSLKHIV TGIIANVDAG KTTLSEALLY QTGNLRNLGR VDNGNTFLDT DQLEKKRGIT
IFSHQANLEY NDLSLTILDT PGHVDFVTQT EQVLSVLDYA ILVISATDGI TSHTRSLWNL
LNHYHIPVFI FVNKIDISTN KASQILSQLK SELDESIIDF SSDNMIEDIA TCDESLFEDY
LQTNTIPDEK ILSLISDRVV FPCYFGSALK LDGIDEFLQG FNHWTQESHY PNNFQVKIFK
ISHNDKGERL TWLRILGGSL KPREEILPEQ KISQIRVYNG EKFSTYPTVN AGQVCTIPGL
VNTYPGLSIG ENQIDTIPTI TPVLSYALDL NGNDIQTCLK ALYELEDEDP KLHVTWSEHL
QEISVQIMGE IQLEILEQLL LDRYNLNVTF TKGNILYKET ITKTIEGVGH FEPLRHYSEV
HLLLEPGKRG SGLQFENQCS LEVLDKNWQH QIISNLKAKE HLGVLTGSPL TDVKITLLGG
KASNVHTVGG DFRQACSRAV RQGLMMLREN NNCQLLEPWY RFRLKVDRTQ IGRAINDIQR
IHGTLDEQQV EGILTGIAPV SEMYNYATNV RAYTHGNGTL ELEIAGYYPC HNSTDIVSQQ
NYDPVSDLEN TPQSVFCAHG AGYTVDWKDV PATMHCEYFW NGMN
//
